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Type 2 diabetes is associated with increased risk of developing dementia
1. Those diagnosed with diabetes before age 60 years had a nearly threefold increased risk for dementia compared to those who never developed diabetes, as per a recent study.
#MedTwitter #diabetes twitter.com/i/web/status/1…
1. Those diagnosed with diabetes before age 60 years had a nearly threefold increased risk for dementia compared to those who never developed diabetes, as per a recent study.
#MedTwitter #diabetes twitter.com/i/web/status/1…
2. Those aged 60-69 years at diabetes diagnosis had 73% higher risk of developing dementia and those aged 70-79 years at diabetes diagnosis had 23% higher risk of developing dementia.
The relationship with dementia was not significant for those aged 80 years and older.
#dementia
The relationship with dementia was not significant for those aged 80 years and older.
#dementia
3. Mechanisms include glucose toxicity, insulin resistance & microvascular dysfunction of the central nervous system.
Glucose toxicity and microvascular dysfunction are associated with increased inflammatory & oxidative stress, leading to increased blood–brain permeability.
Glucose toxicity and microvascular dysfunction are associated with increased inflammatory & oxidative stress, leading to increased blood–brain permeability.
4. Take home message
*Earlier age of onset of diabetes substantially increases dementia risk. Efforts should be made to prevent or delay diabetes.
*Preventing or delaying progression of prediabetes to diabetes will reduce dementia burden.
*Earlier age of onset of diabetes substantially increases dementia risk. Efforts should be made to prevent or delay diabetes.
*Preventing or delaying progression of prediabetes to diabetes will reduce dementia burden.
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