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Genome Informatics @isugif
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#PAGXXVI #pag2018, @zevkroenberg Comparative analysis of great ape: 1. structural variation is the largest source of genetic novelty. Every human has ~3mbp of Structural variants
#PAGXXVI #pag2018, @zevkroenberg Comparative analysis of great ape: 2. re-sequenced orangutan, gorilla and human to find structural variants between them.
#PAGXXVI #pag2018, @zevkroenberg 3. Comparative analysis of great ape: 3. SMRTie-SV a new tool for discovering structural variants across species. Finds lineage specific SVs as well.
#PAGXXVI #pag2018, @zevkroenberg Comparative analysis of great ape: 4. Novel human specific deletion of CARD8, removes 13 exons that are in all the great apes from human genome
#PAGXXVI #pag2018, @zevkroenberg Comparative analysis of great ape: 5. reannotated the great ape genomes using isoseq, found a novel exon in gorilla in FADs gene cluster.
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#Analysis: Ending #BirthrightCitizenship for the children of illegal immigrants and birth tourists has long been the crown jewel of pro-sovereignty immigration reformers. It's about interpreting the #14Amendment of the #Constitution correctly. Thread.
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Second, #14Amendment was one of three emancipation-related amendments to the #Constitution, designed to grant citizenship to former slaves and their children. The congressional record shows nobody believed 600,000 Americans died to give Congress the chance to open the borders.
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Genetic differences between human populations: more than meets the eye (link thread):
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Comparative analysis is literally one of my favourite things in the world!

In trying to explain differences, we're forced to step back, identify key features that we otherwise took for granted, & think more rigorously about the drivers of change, or continuity. #thread
So I was VERY excited to read this new @OUPAcademic book by @HazelSophiaGray!

Comparative analysis of two, formerly very poor countries, with histories of strong state intervention, and subsequent economic liberalisation. 😃
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Why has poverty fallen more rapidly in Vietnam than Tanzania?
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Le grand oublié du #PAG au #Bénin : le #tourisme religieux benindufutur.org/BDF/opportunit… #wasexo @gouvbenin @RevealingBenin @DallysTom #beninenchantier
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#PAGXXVI Jay Shendura will give the plenary talk this morning: Beyond Sequencing: New Frontiers In Genomics.
He starts with history: the mapping of every cell in nematodes. Why haven't we done that for other organisms? Other organisms have more complex cell lineage trees.
Single cell combinatorial indexing ("sci-") See Cusanovich et al (ATAC) sci 2015, Ramani et al Nat Methods 2017, Vitak et al Nat Meth 2017, Cao et al Science 2017, Mulqueen et al BioXriv. Or google that term.... nature.com/articles/nmeth…
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I could say so much here at this point about how &why the systems underlying running of all social media platforms are of limited use #human
2 But a stifling #culture 's been bred,like the valley of the squinting windows,in which you're not supposed to go out of your understanding
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