Will @Dichtel is getting the last day started with remarkable work on the improved synthesis of COFs. He won’t touch the apps since many talked earlier and there’s a lot to discuss for the COF mechanisms #POLYMATsptl 
How crystalline are COFs? Particles are typically in microns and roughly 50 nm thick #POLYMATsptl
Some daunting questions that needs answering for COFs #POLYMATsptl
Although solubility is a hassle COF-5 is the fruitfly of COFs and offers good platform. They found out one doesn’t need all 36 hours to get good product. #POLYMATsptl
Pyrene and diacetylene linkers are isomeric, and gives nice comparisons. Pyrene is much superior for its enhanced pi stacking properties #POLYMATsptl
The missing piece of the puzzle is how nucleation is taking place says Will @Dichtel. He also believes oligomers are the key for crystallinity #POLYMATsptl
Nitrile solvents prevent any precipitation in COF synthesis by stabilizing colloidal particles says @Dichtel #POLYMATsptl
Slow addition of monomers to a stable collodial COF solution yields single crystals! #POLYMATsptl
Imine COFs are totally different. As @fzamora0 elaborated yesterday, amorphous to crystalline transition happens even if polymer was separated and reintroduced says @Dichtel #POLYMATsptl
To study the mechanism for imine COFs @Dichtel studied macrocycles that surprisingly form in 75% when a fiod solvent like THF is used. And TFA is critical as catalyst to sustain dynamic covalent chemistry. Even polymer redissolves #POLYMATsptl
Imine macrocycles stack after heavily protonated and become stable for heavy acid presence says @Dichtel. But model compounds of bis imines are not! This work is also up at @ChemRxiv #POLYMATsptl
Beta ketoenamine COFs don’t usually give high quality crystals. But aldehydes could be swapped! This work is done by an undergrad. #POLYMATsptl
Will @Dichtel ends his talk with take home message that one can control the growth of COFs #POLYMATsptl
@threadreaderapp unroll @Dichtel
