@markdhumphries @cian_neuro @marius10p @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun Thanks Mark! A few answers on E/I balance. Re: Experimental influence, yeah, I'd say the early E/I papers by @HSompolinsky et al. were definitely an inspiration for the field & I'd say it's the constant T&E interplay that makes the EI balance example great ncbi.nlm.nih.gov/pubmed/8939866
@markdhumphries @cian_neuro @marius10p @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun @HSompolinsky @shadlen & Newsome had been thinking about the origins of irregular firing for a long time, & theory provided an explanation for what they saw. I think the first people to actually record EI balance were Moore & @SachaNelsonLab physiology.org/doi/abs/10.115… in parallel w/ the theory.
@markdhumphries @cian_neuro @marius10p @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun @HSompolinsky @shadlen @SachaNelsonLab The follow up experimental papers by Wehr & Zador & Shu et al, both 2003, then drove the story home, and pointing towards more interesting questions. ncbi.nlm.nih.gov/pubmed/14647382 & ncbi.nlm.nih.gov/pubmed/12748642
@markdhumphries @cian_neuro @marius10p @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun @HSompolinsky @shadlen @SachaNelsonLab From that point on, it’s been a constant back & forth, elaborating on the concept going from global ”@HSompolinsky” balance to more precise versions of it, both spatially and temporally, like shown by @michael_okun : ncbi.nlm.nih.gov/pubmed/18376400
@markdhumphries @cian_neuro @marius10p @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun @HSompolinsky @shadlen @SachaNelsonLab More people than can be named here have contributed to the progress of understanding network interactions as a direct result of the interaction of E&I but there is a bunch of reviews on this stuff, including from my lab and from @sprekeler & @sprekeler neurotheory.ox.ac.uk/~timv/pub/Henn…
@markdhumphries @cian_neuro @marius10p @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun @HSompolinsky @shadlen @SachaNelsonLab @sprekeler In any case, to discount that over 20 year long experimental-theory collaboration as “zero” evidence for the value of theory seems a bit harsh. Maybe I got a bit too cranky at @marius10p, fair enough.
@markdhumphries @cian_neuro @marius10p @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun @HSompolinsky @shadlen @SachaNelsonLab @sprekeler The latest and really nice piece of evidence for this ongoing E&T interaction comes from @FMIscience, showing tight and detailed balance in Zebrafish, and yeah, it’s directly inspired by theory, as described in their intro. cell.com/neuron/pdfExte… SO COOL.
@markdhumphries @cian_neuro @marius10p @ulisespereirao @neurograce @computingnature @bitking69 @CousinAmygdala @michael_okun @HSompolinsky @shadlen @SachaNelsonLab @sprekeler @FMIscience Also, my ad hoc oral history of E&T balance probs leaves out many papers, sorry IMO, theory W/O experiment has value, and vice versa, too. It's even nicer when we can do it together, but collaboration can happen generationally, and it doesn't matter if theory is post- or pre hoc.
