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Reverse Signaling by Semaphorin-6A Regulates Cellular Aggregation and Neuronal Morphology dx.plos.org/10.1371/journa… - one of ours from a few years ago, giving biochemical insights into combinatorial coding of guidance molecules
Neurodevelopmental molecules, like sempahorins and plexins, are not devoted to specific functions in specific regions. They are deployed in many different contexts all over the developing brain, controlling diverse cellular processes...
As expertly reviewed here by @JeroenPasterk: Getting neural circuits into shape with semaphorins. ncbi.nlm.nih.gov/pubmed/22895477
This lack of functional dedication (which is typical) is partly why mutations affecting neurodevelopmental processes tend to have such pleiotropic effects
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