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HDL and ApoA1 better discriminators of disease than apoB. For severity of disease apoB showed weak correlation (<0.3); overall ratios clearly best.
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Later report on all-cause mortality (ACM) found "no significant prediction of ACM by various lipid and lipoprotein parameters" - ncbi.nlm.nih.gov/pubmed/19849748
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Note: for apoB to be a relevant predictor it needs to be proven that it is better than the TC/HDL ratio. Majority of studies show that it is not better or actually worse.
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Similar was seen in a later analysis - ncbi.nlm.nih.gov/pmc/articles/P…
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Very interesting data in the supplement for fatal CVD where HDL and ApoA1 were the strongest (inverse) predictors.
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apoB no better than HDL for CV events.
Assoc. for apoB weaker in some groups (women, elderly, lower triglycerides i.e. apoB relations depend on other factors).
Low cholesterol ⬆️ CV deaths.
Low HDL or ApoA1 bigger risk factors than apoB for CV death.
The Kitavans, who appear absent of CVD, have apoB levels generally on the higher end well-above recommended levels (<90 mg/dl).
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