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Kevin Mitchell

@WiringTheBrain

, 4 tweets, 1 min read Read on Twitter

@siminevazire

@siminevazire

The Reproducibility Wars: Successful, Unsuccessful, Uninterpretable, Exact, Conceptual, Triangulated, Contested Replication clinchem.aaccjnls.org/content/63/5/9… by John Ioannidis, HT @siminevazire

From psychology to clinical lab science, the dynamics are largely the same...

"Currently, it is notoriously difficult to publish somewhere that “I have not been able to make this laboratory method work” in the peer-reviewed literature, although it is one of the most common frustrating experiences of any laboratory scientist."

The voodoo defense - you couldn't see the claimed effect because you didn't do the experiments in just the right way, when the moon is full, and the spirits are smiling...

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https://twitter.com/Jahaza/status/1096652126363750400

Kevin Bass, MS

@kevinnbass

Much of the low-carbohydrate diet movement is fraud. A thread. 1/n

The purpose of this thread is not to show that low-carbohydrate diets do not work. Low-carbohydrate diets do work for many people. 2/n

The anti-inflammatory properties of the ketogenic diet are interesting and potentially important, as are the brain effects. We need more research on these, and we should use ketogenic diets when they can be useful. 3/n

Read 149 tweets

@davidludwigmd

@JohnSpeakman4

Kevin Bass

@kevinnbass

Let's talk Lipoprotein(a) and cardiovascular disease risk.

(Hereafter,

Lp(a)=Lipoprotein(a),
CVD=cardiovascular disease.)

Thread. 1/n

Lp(a) blood level show a dose-response relationship to cardiovascular disease risk in multiple studies, and Lp(a) is now widely considered a reliable marker for CVD risk.

Here is a graph showing ~4-fold increased risk at >95th-percentile Lp(a) level.

circ.ahajournals.org/content/117/2/… 2/n

[Above is adjusted for age (left) and multifactorially (right). Latter: age, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apoB, BMI, hypertension, DM, smoking, lipid-lowering therapy, and, for women, menopause and HRT.] 3/n

Read 155 tweets

Prof Darrel Francis [cardio logically speaking]

@ProfDFrancis

Considering #statin in 35-y-o man worried about extensive family history of MI+stroke: 2 parents, 3 of 4 sibs.

#Cholesterol 5.8 mM, 224 mg/dl. Subtypes typical for such a total.
Non-smoker. Otherwise average.

[Live-quiz from #orbita-HQ for #cardioTwitter fellows & the curious]

Question C2.

First vote was for diet first, and quite right too! That is the guideline, and we must obey.

Natural, organic, eco-friendly and therefore best.

What effect size is a reasonable expectation, for patient and Dr, for the reduction of total cholesterol by diet?

Question C3.

(currently 0.8 mmol/L in the lead for Question C2)
There are several ways to choose a value. Which did you use?

Read 47 tweets

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