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I will thread some scientific information behind the $100 genome claim. 1/
2/ First of all, claim comes from Rade Drmanac, scientific founder of Complete Genomics, acquired by BGI, now called BGI Group, and part of instrument subsdiary MGI. Got that?

BGI GROUP
\
MGI Tech
\
Complete Genomics
3/ Their method doesn't use PCR to amplify the DNA. Allegedly makes it more accurate.

preprint:

Whole Genome Sequencing Using a Complete PCR-free Massively Parallel Sequencing (MPS) Workflow biorxiv.org/content/10.110…
4/ They don't have to label the DNA letters, AGCT, with fluorescent stuff. use natural nucleotides but mark them w/ antibodies. better signal suppsdly

CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase biorxiv.org/content/10.110…
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Antonio Regalado
@antonioregalado
Are you gassing up the car, stocking up on food, or making for your cabin?

If you are a technologist preparing for the coronavirus, want to share prep stories, or think personal preparation is dumb, please DM me...or post ideas to this thread!
First of all, let's revisit the poll I ran last month and see what changed.

Have you done any "pandemic shopping" yet? Bought masks, food, or water?
Here are results of same poll, last Jan 28th.
Read 4 tweets
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Antonio Regalado
@antonioregalado
many hopes pinned on remdesivir, experimental anti-viral drug.

It's for RNA viruses. Previously tested against Ebola, Nipah, MERS, in lab settings + animals.

Mechanism is classic wrench in the works. drug metabolized into ersatz nucleotides that mess up viral replication. 1/3
The drug is owned by Gilead, which used similar strategy of fake nucleotides to create its Hep C blockbuster, Solvadi. 2/3
An antiviral drug that beats coronavirus would be a lot more actionable than a vaccine in the near/medium term. 3/3
Read 3 tweets
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Antonio Regalado
@antonioregalado
Group in Switzerland has recreated the coronavirus in part from synthetic DNA.

They ordered the genetic parts from a Chinese company, Genscript

(1/thread)

biorxiv.org/content/10.110…
This is a record. The sequence went online January 14th and this team managed to recreate the virus about a month later.
2/
It wasnt wholly synthetic. They ended up getting a copy of the genome of the real virus from which they grabbed a couple of bits that proved hard to synthesize.
3/
Read 5 tweets

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हठयोगी
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Rev. Jeremy Smith
@umjeremy
#Thread for reflections, commentary, and snark on the Pre-General Conference briefing in Nashville. This is billed as more “informational” than “conversational” event—so those aspects will be here!

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@warriorhasi_iaf
#Thread 📍
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🔸What is POK?
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#Thread Senator @HawleyMO With Perhaps the Greatest America First Speech Ever Given:

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@GOPoversight
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