Recent @CellCellPress #COVID19 study on #immunity helps explain why these 2pts with X-linked agammaglobulinemia (genetic immunodeficiency where pts have complete abscence of Bcells: inability to produce antibodies) developed COVID19 pneumonia—but RECOVERED
onlinelibrary.wiley.com/doi/abs/10.111…
2/In another recently published case #COVID19 study in @AnnalsAllergy—pt with another genetic immunodeficiency (common variable immunodeficiency on monthly IVIG w/stable bronchiectasis) had #COVID19 but fully recovered after ICU care despite increased risk
annallergy.org/article/S1081-…
3/ Of note, CVID pt with #COVID19 also had breast cancer in remission on tamoxifen OD, hypothyroidism & Sjögren’s on #hydroxychloroquine 200mg BID. She presented to ER on D7 of symptoms. Her home dose of hydroxychloroquine was incr to TID w/IVIG. No azithromycin d/t known allergy
4/ #Immunosuppression may be beneficial in preventing mortality, increasing syndromes of hyperinflammation & cytokine storm brought about by COVID-19 activating host immune responses, including interleukin (IL)-2, IL-6, IL-7, ferritin, & tumor necrosis factor-alpha among others”

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More from @dockaurG

4 Sep
1/ US & UK media finally reporting what we've known for months from published peer-reviewed research by leading scientists🌎: pre-existing cross-protective Tcell immunity & strong Tcell responses bode well for long-term #SARSCoV2 immunity, and #HerdImmunity may already be at hand
2/ US: "We may be closer to #HerdImmunity than previously thought. Are we fearing a ‘second wave’ which our immune systems already have well in hand? People show immunological response to #SARSCoV2 in their Tcells.. without necessarily showing antibodies."
spectator.us/closer-herd-im…
3/ "#HerdImmunity may be closer than thought—UK scientists say immunity likely far higher than what govt antibody tests shows b/c it doesn't account for Tcells. Top immunologists said infection-fighting Tcells are more durable/long-lasting than antibodies"
dailymail.co.uk/news/article-8…
Read 4 tweets
6 Jul
Pls read #SARSCoV2 immunology🧵& subthreads for what media & “experts” are not telling you

Facts
-we have some pre-existing cross-protective immunity
-basing herd immunity only on antibodies omits strong Tcell immunity
-vaccine candidates not effective b/c don’t elicit IgA prodn
2/ Last week, researchers in Sweden and Germany also found strong T-cell responses to #SARSCoV2 which bode well for long-term immunity & found pre-existing cross-protective immunity: findings are consistent with the original US Cell study published in May.
3/ We now have three independent #SARSCoV2 studies, from teams of scientists in three different countries, all concluding the same thing:

#COVID19 Herd Immunity Is Much Closer Than Antibody Tests Suggest”
reason.com/2020/07/01/cov…
Read 13 tweets
5 Jul
53+ published #HCQ studies in #COVID19—strong efficacy as prophylaxis & as treatment in early COVID19. HCQ is std of care in COVID19 tx protocols for many countries🌎 w/lowest fatality rates. Govts allowing ppl to die by blocking access to life-saving meds
c19study.com
2/#HCQ activates host anti-viral innate immunity—strong efficacy as prophylaxis & as treatment in EARLY #COVID19 esp w/in 5d of symptoms. Now we know why

CDC: >88% don't yield replication-competent #SARSCoV2 virus after 10d & viral shedding drops after 6d
cdc.gov/coronavirus/20…
3/ Recent pre-print systematic review & meta-analysis on "#SARSCoV2 viral load dynamics, duration of viral shedding & infectiousness" found:
"SARSCoV2 titres detectable in first week of illness with early peak observed at symptom onset to day 5 of illness"
medrxiv.org/content/10.110…
Read 5 tweets
4 Jun
Based on published #HCQ studies & case-controlled clinical trials, HCQ has significant efficacy in early treatment of #COVID19: PRE-exposure prophylaxis & early POST-exposure treatment. Recent NEJM RCT focused on NEITHER of these 2 key groups but rather: POST-exposure prophylaxis
2/ Here’s link to NEJM #HCQ RCT published today on POST-exposure prophylaxis given up to 4d AFTER exposure. Disturbing that science was again politically sensationalized by media before study was even published w/quotes from MD with #Gilead #BigPharma COI
nejm.org/doi/full/10.10…
3/ “The results reported by Boulware et al. are more provocative than definitive, suggesting the potential prevention benefit(s) of #Hydroxychloroquine remain to be determined,” concluded Dr. Myron Cohen MD in NEJM editorial re recent NEJM HCQ #COVID19 RCT
nejm.org/doi/full/10.10…
Read 4 tweets
26 May
Imp Thread: public health fallacy to claim popn #SARSCoV2 IgG serology tests capture all pts recovered from #COVID19: grossly UNDERestimates % popn that was asymptomatic & recovered. Key arms of immune response to #SARSCoV2: humoral with antibodies & cell-mediated with T-cells
2/ Current public health method to estimate population immunity to #SARSCoV2 from recovered asymptomatic #COVID19 ppl uses serology tests to detect IgG antibodies: this only captures humoral immunity. Currently no widely available testing kit for T-cell immunity to #SARSCoV2
3/ Pts mount strong T-cell immune responses to #coronaviruses. Published Cell research & studies on recovered #COVID19 pts w/immunodeficiency disorders w/inability to mount B-cell responses to #SARSCoV2 reveal B-cell antibody responses not strictly required to overcome COVID-19
Read 6 tweets

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