Recent @CellCellPress #COVID19 study on #immunity helps explain why these 2pts with X-linked agammaglobulinemia (genetic immunodeficiency where pts have complete abscence of Bcells: inability to produce antibodies) developed COVID19 pneumonia—but RECOVERED
onlinelibrary.wiley.com/doi/abs/10.111…
onlinelibrary.wiley.com/doi/abs/10.111…
2/In another recently published case #COVID19 study in @AnnalsAllergy—pt with another genetic immunodeficiency (common variable immunodeficiency on monthly IVIG w/stable bronchiectasis) had #COVID19 but fully recovered after ICU care despite increased risk
annallergy.org/article/S1081-…
annallergy.org/article/S1081-…
3/ Of note, CVID pt with #COVID19 also had breast cancer in remission on tamoxifen OD, hypothyroidism & Sjögren’s on #hydroxychloroquine 200mg BID. She presented to ER on D7 of symptoms. Her home dose of hydroxychloroquine was incr to TID w/IVIG. No azithromycin d/t known allergy
4/ “#Immunosuppression may be beneficial in preventing mortality, increasing syndromes of hyperinflammation & cytokine storm brought about by COVID-19 activating host immune responses, including interleukin (IL)-2, IL-6, IL-7, ferritin, & tumor necrosis factor-alpha among others”
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