Thread by @dockaurG

Based on published #HCQ studies & case-controlled clinical trials, HCQ has significant efficacy in early treatment of #COVID19: PRE-exposure prophylaxis & early POST-exposure treatment. Recent NEJM RCT focused on NEITHER of these 2 key groups but rather: POST-exposure prophylaxis

https://twitter.com/dockaurG/status/1265447098381676544

2/ Here’s link to NEJM #HCQ RCT published today on POST-exposure prophylaxis given up to 4d AFTER exposure. Disturbing that science was again politically sensationalized by media before study was even published w/quotes from MD with #Gilead #BigPharma COI
nejm.org/doi/full/10.10…

3/ “The results reported by Boulware et al. are more provocative than definitive, suggesting the potential prevention benefit(s) of #Hydroxychloroquine remain to be determined,” concluded Dr. Myron Cohen MD in NEJM editorial re recent NEJM HCQ #COVID19 RCT
nejm.org/doi/full/10.10…

4/ As with all other #HCQ #COVID19 studies to-date, RCT showed NO cardiac toxicity to #Hydroxychloroquine. Many design limitations: all pts not tested, med & study compliance stated as “moderate” & heavy reliance on pts self-reporting symptoms instead of clinical assessment by MD