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🚨BREAKING: Retrospective study of 96,000 hospitalized #coronavirus patients finds that patients who received #chloroquine or #hydroxychloroquine—called a “game changer” by @realDonaldTrump—had a significantly HIGHER risk of DEATH vs. those who did not.💥
washingtonpost.com/health/2020/05…
This huge study in @TheLancet found ZERO BENEFIT of #hydroxychloroquine or #chloroquine, but people treated with either drug were MORE LIKELY to develop a type of potentially FATAL irregular heart rhythm (ventricular arrhythmia), that can lead to sudden cardiac death.💥
Link to the full study results, published in Lancet.👇🏼

marlin-prod.literatumonline.com/pb-assets/Lanc…
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Dr. Dena Grayson
@DrDenaGrayson
⚠️Scientists estimate that "superspreaders" may account for most #coronavirus cases: “Probably ~10% of cases lead to 80% of the spread," and the virus may need to be introduced into a country 4 times to have an even chance of establishing itself.

sciencemag.org/news/2020/05/w…
Multiple “superspreading events” have occurred in the #CoronavirusPandemic:

▶️61 cases in a #WA choir
▶️800 cases in a Singapore dorm
▶️80 cases at a music venue in #Japan
▶️Ships, nursing homes, meatpacking plants, ski resorts, churches, restaurants, hospitals, and prisons
Superspreading events are ill-understood and difficult to study, but there is a much higher risk in enclosed spaces than outside. Outside the #Wuhan region in #China, there were 318 clusters of ≥3 cases btwn 4 JAN and 11 FEB: only 1 originated outdoors.💥
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Dr. Dena Grayson
@DrDenaGrayson
⚠️Good news! 1st peer-reviewed report of a #coronavirus vaccine study shows promising results in 108 participants:

▶️No serious safety signals
▶️78% in low-dose, 92% in mid-dose, and 100% in high-dose groups developed neutralizing antibodies or a T-cell response to #SARSCoV2.
Based on studies of those who recovered from #COVID19, the spike protein on the surface of the #coronavirus is a key target of the immune system.

This vaccine uses an adenovirus—it cannot replicate but expresses the #coronavirus spike protein.

@TheLancet
thelancet.com/action/showPdf…
This report from a phase 1 study is encouraging, but there’s still a long way to go. That said, we now have MULTIPLE #vaccine shots on goal, and I’m increasingly optimistic that we will eventually have an effective #coronavirus vaccine.🤞🏼

#COVID19
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Dr. Dena Grayson
@DrDenaGrayson
⚠️Right ventricle (RV) enlargement was the best predictor of which severe #COVID19 patients were most likely to die. RV enlargement can be caused by high blood pressure in the lungs (pulmonary hypertension) via clots, lung damage, obesity...

@thespybrief
cnn.com/2020/05/18/hea…
RV enlargement way be associative, not causative, for increased risk of death from #coronavirus.

Increased lung damage and/or clots in the pulmonary vasculature▶️pulmonary hypertension▶️RV enlargement

#COVID19
👇🏼Link to the published single-center study in @JACCJournals.

Of 105 #COVID19 patients, 31% had dilation of the RV based on an echocardiogram. Of these, 41% died by the end of the study period, compared to 11% of those without RV enlargement.

imaging.onlinejacc.org/content/jimg/e…
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