1/6 @quantum_si represents the next logical step for my work in massively-parallel DNA sequencing (next-generation DNA sequencing, NGS) and proteomics. My teams created the NGS field in 2005 (454 Life Sciences) and with it changed life sciences and medicine forever. ImageImage
2/6 We had the covers of both Nature and Science for our proteomics work, and were first to move NGS onto a semiconductor chip with Ion Torrent. ImageImage
3/6 With @quantum_si we have created the world's first semiconductor chip to enable next-generation PROTEIN sequencing and single molecule proteomics. Image
4/6 We combine our chip with a true end-to-end solution that includes sample preparation and data analysis, along with a second ultra-low cost version of our instrument we will use to bring proteomics to the home. Image
5/6 While our DNA tells us what could happen, single molecule proteomics tells us what is about to happen, providing greater insights and ultimately better treatments for human disease. My dream includes seeing a heart attack coming days before it happens.
6/6 We are doing for proteins what we previously did for DNA and are ideally positioned to disrupt, expand, and “make digital” the $36B proteomics market.

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More from @JMRothberg

24 May 20
Super exciting day. 78 days ago saw my lab and thought we need to help fight #Covid. Today I’m running our Covid Detect At-Home test. A sensitive presymptomatic molecular test for the rest of us. Scaling as I tweet to millions & 10s of million per month.
Just ran Covid Detect At-Home test for the first time on myself!

So simple. Swab and go!
and...

Well I’m human, the nose collection control worked (we test for human gene).

And I’m NOT positive for #Covid.

Total Game changer!

Real molecular testing anywhere. By anyone.
Congratulations to the best team on earth @4Catalyzer & @HomodeusInc.

You went from an idea on March 7th to a product I could use on myself. And a product in production to scale to meet the testing needs of planet earth.

A true molecular test, without the PCR machine or lab!
Read 4 tweets
17 Mar 20
Reporting progress on #coronavirus Home Test from our teams internal email: Just wanted to give a brief update from the #molbio team as we build momentum towards delivering an at-home, user-friendly, rapid #COVID19 test...We are actually detecting Covid19 #RNA in solution now! 1/
... we got early proof today that we can do reactions from RNA (the genetics code of #SARSーCoVー2 not DNA so it’s more insidious). Our method (which amplified the RNA without a machine) is very tolerant of #saliva - (we still have to crack open the virus RNA for full proof) 2/
The parenthesis in the above tweets are my commentary and I also edited out jargon. But wanted to share our internal optimism. We now know, except for breaking the #virus open to expose its #RNA we should be able to do a #COVID19 test without a #PCR machine @yale and @Penn 3/
Read 11 tweets
7 Mar 20
Thinking about a low cost easy to manufacture home test kit for #Coronavirus. Outline: #Nasal_swab (Q-tip) w/ freeze dried reagents for isothermal #DNA amplification with #COVID19 primers. Colorimetric readout by #iOS or #Android #App w/ #geolocation & #HIPPA compliant reporting. Image
Read-out would be in minutes - timer in App - read by camera in your smart phone. No other machines. Links to telemedicine groups for positive results. Built in positive control - e.g. no color = improper test, green NEGATIVE, red POSITIVE.
I’ve done my best creating when faced by a challenge. Next gen sequencing when my son went to new born intensive care - #454 @iontorrent. Ultrasound on a chip @ButterflyNetInc when wanted to monitor my daughter’s kidneys.
Read 31 tweets

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