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12 Feb, 6 tweets, 3 min read
1/
 Large RCT (n=930) in Barcelona, 🇪🇸: #calcifediol vs control among hospitalized #COVID_19 patients.
Strong clinical benefit: ↘️ICU admission & ↘️mortality.
Unclear to me why this preprint got unnoticed (published three weeks ago) !
#VitaminD
papers.ssrn.com/sol3/papers.cf…
2/
These new results confirm similar positive results for calcifediol generated in Cordoba in a smaller pilot RCT
3/
The new study in Barcelona has limitations: no placebo (open label); randomization per ward (not individual); modified intention to treat for some patients.
Yet results are very encouraging !
It was apparently submitted to @TheLancet. I hope it will get published soon.
4/
 Calcifediol is a metabolite of cholecalciferol (Vitamin D3). "Calcifediol was preferred to other available vitamin D metabolites because of its excellent intestinal absorption
and rapid replenishment of 25OHD serum levels."
5/
Conversely, cholecalciferol (D3) takes about 7 days to be metabolized & become active. This may explain the disappointing results of cholecalciferol in hospitalized patients in this study in 🇧🇷.
6/
 Finally, note that calcifediol (unlike cholecalciferol) is not available over the counter. It is a prescription drug. In 🇫🇷, brand name is Dedrogyl and it is quite cheap (€6). doctissimo.fr/medicament-DED…

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More from @julienpotet

Julien Potet Profile picture
11 Feb
Live-tweeting about the 1st online conference on noma disease. Stay tune !
#ZeroNoma #NTDs
Opening message by @PeterHotez. Peter is among other things editor of @PLOSNTDs. The journal recently agreed to include noma in the list of eligible diseases for publication. #NTDs
Noma survivor @FidelStrub tells his personal story. Underwent 27 surgical operations ! Moving testimony by a strong advocate !
Read 18 tweets
Julien Potet Profile picture
11 Jan
Bangladesh: large RCT (n=606) of #mouthwash, gargling, nasal spraying & eye drops w/ 1% povidone-iodine (PVP-I, aka #Betadine) for #COVID_19. Every 4 hours for 4 weeks.
Impressive results.
bioresearchcommunications.com/index.php/brc/…
h/t @Covid19Crusher
Mouthwash solutions of PVP-I can be easily purchased OTC in many countries. Nasal sprays and eye drops are less easily accessible (i.e. not available OTC in France).
There have been other in vivo and in vitro studies over the last months. A tiny RCT from Singapore had previously found encouraging results.
Read 5 tweets
Julien Potet Profile picture
7 Dec 20
1/
 There have been several small RCTs over the last weeks suggesting a clinical benefit for #ivermectin for #COVID_19.

It’s time for a MEGA THREAD on ivermectin, aka the “wonder drug”!

Let's start the show !🔥🔥🔥
2/
Ivermectin belongs to the family of avermectins, which are natural fermentation products of soil bacteria. A Nobel Prize of Medicine was awarded for their discovery. Image
3/
Ivermectin is indicated for several parasitic infections: onchocerciasis, lymphatic filariasis, strongyloidiasis, scabies. It works on head lice too. #NTDs

But ivermectin may have a broader therapeutic benefit. Hence its nickname, the “wonder drug”.
pubmed.ncbi.nlm.nih.gov/28196978/
Read 20 tweets
Julien Potet Profile picture
19 Apr 20
1/
In this thread, I’ll speak about #tocilizumab and challenges to access it. Tocilizumab is an anti-IL-6-receptor monoclonal antibody. It is a promising investigational drug to treat the cytokine storm associated with severe #COVID19.
2/
The cytokine storm (aka cytokine release syndrome) occurs when a high number of white blood cells are activated and release inflammatory cytokines, such as IL-6, which in turn activate more white blood cells.
3/
Tocilizumab is not an antiviral agent. Like other host focused therapies for COVID19, tocilizumab can be used in association with an effective antiviral and their combined actions may be complementary.
Read 22 tweets
Julien Potet Profile picture
12 Mar 20
In this thread, I’ll share what is known about access to #remdesivir, one of the leading therapeutic candidates against #COVID19. Originator company @GileadSciences ($GILD). As an introduction, I suggest you should read this very detailed article. biopharmadive.com/news/coronavir… 1/n
Remdesivir (aka GS-5734) inhibits RNA-dependent RNA polymerase. Broad-spectrum antiviral. Injectable (IV). Wasn’t found as clinically effective for #Ebola as monoclonal antibodies. Here is the formula. The synthesis of GS-5734 is described here. pubs.acs.org/doi/full/10.10… 2/n
How much of remdesivir is available now ? Unclear. In Feb 2019, when drug was still a promising candidate for #Ebola, Gilead planned to have 25kg + 4x40g of (unfinished) drug substance by 2020, equivalent to 148,000 treatment courses. Unknown if it materialized. 3/n
Read 12 tweets

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