$BEAM 4Q20 results out. Valuation is crazy but they are the best of #Crispr breed in my opinion given execution to date. #GeneTherapy 1/
$BEAM focus on platform, delivery and manufacturing is enabled by share price and ability to source funds without huge dilution 2/
$BEAM focus on based editing of transition mutations. 3/ #dreaminase
$BEAM is both in-licensing and out-licensing which makes sense given funding ability and fields of interest 4/
$BEAM ties to Broad and Harvard are more costly given valuation ties to agreements. Derivative liability increase in C20 show impacts. 5/
Feb $BEAM acquisition of Guide and private placement only drove 9% dilution. Nice to be able to extend runway by 1.5 years and bring in delivery capabilities for relatively low cost 6/6
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$SNY looks like they are ready for a Genomic Medicine Unity #GMU coming out year in C21. Many hires. Many open reqs. Building on Ablynx, Bioverativ and Kiadis M&A #GeneTherapy
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$SNY #GMU head of Rare and Neurologic Disease Research is Christian Mueller. Video into is pretty good
Addl heads include Bruno Figueroa (CMC) and Cate O'Riordan (translational unit)
2/
$SNY #GMU Principal Scientist Robert Jackson profile says he is working on: Huntingtin's, MLD, PKU, Neurophathies, T1Diabetes Hypertension, Nephrophaty, vascular disease, Rheumatoid Arthritis and sensorineural hearing loss
3/
Part II of the $CRSP $SGMO comparison will hopefully be a bit less dry now that Part I updates are in place. This thread will focus more on valuation, outlook and why the valuation cycle should matter to investors.
1/
Let's start with the concept of #Disruptive technologies. The originator of disruptive innovation theory, Clayton Christensen worked with HBR in 2015 to revisit the past 20 years. 2/ hbr.org/2015/12/what-i…
#GenomicMedicine is disrupting Big Pharma who has begun to respond by spinning off old product lines and jumping into #GeneTherapy. 3/
This is the third edition of my tweetstorms on #GeneTherapy#CellTherapy#GeneEditing. This one compares $SGMO to $CRSP and attempts to look at #GenomeMedicine from the perspectives laid out by C.Woods at ARK This is part one of the series. Pt 2 tomorrow AM 1/20
The charts of both are attached and useful context. $CRSP went public in 2016. The weekly chart is attached and notes the pct ownership of $ARKG $ARKK since CY18. Prior the stock was stagnant below the support/resistance levels show. 2/20
I'm including two charts for $SGMO. Wkly and Mthly. The weekly shows they were pulled along with the #geneediting group The monthly shows this rally/bust cycle is not unique. Compare the SGMO 2017-2018 to CRSP. Pretty similar. More later. 3/20
Appears Cowen published a useful courtesy $SGMO rept for investors prior to their annual HC conference. Most of the verbiage is an accumulation of prior reports. They have higher model royalties for $PFE and $SNY royalties than mine. Not a SOTP or full blown model
Cowen states that though the prelim data on $SNY collab was unimpressive, they are cautiously optimistic. My fcst was pushed out several years consistent with $BLUE issues and probability that more issues will crop up for $CRSP and $SGMO programs.
Attached screenshot of Cowen P&L is consistent with reported $SGMO revenue in C19 including:
- Research reimbursement $16m (mostly Gilead/Sanofi)
- Upfront amort $46m
- Milestones $39m
$ARKG Tweet series
This series of tweets is my opinion only. Cathie Wood has created a group of ETFs that target the disruptive innovation that is both happening and accelerating. These funds have had stellar performance based upon innovation trends and economic theory. 1/
The $ARKG fund description is a good place to start. This has changed recently to a #CRISPR theme but started more with the sequencing cost declines which would drive diagnostics adoption and precision medicine 2/
The economic driver of the Genomic Revolution is a multiplier. Not only sequencing cost declines but the impact of moving from #ZFN to #TALENs to #CRISPR is key. As the editing cost has dropped CRISPR is seeing a dominant increase in publications. 3/
What's up with $SGMO valuation? This thread will try to show some history and the setup for what I still hope to be an outsized move. First worth noting that news will always trump technicals. First here is a month chart I've been using for the company 1/
This being a 10 year chart, it doesn't show how long $SGMO has been around but it does show virtually no trading volume and a 3 yr ceiling on the price as they were in early development stage while trying to get ill-chosen indications into pre/clinic 2/
The first wave $SGMO rally started in 2013 when the ceiling was broken. The company was talking up #GeneEditing#GeneRegulation#HIVcure and #diabetes None were ready but the volume picked up and the first big rally ensued going from around $9 to $20 3/