#OpenThread - Friday Musings...

Long before streaming existed I dreamt of the wonderful day I wouldn’t have to physically get media (like VHS or DVD) to play it. But now that we’re here, do I miss the joy of owning, the cover art, the collecting?

Nope. Not even a little.
... I’m definitely an MCU fan boy, but I continue to be incredibly impressed at the whole story behind the campaign to make #ZackSnyder’s Justice League cut for @hbomax a reality and the persistent campaign to #restorethesynderverse. Seems like anything is possible now.
I love cheese.

and I make no apologies for this love

it is a True Love – one that will never die
... One of my low-carb friends regularly says, “The only thing more popular than keto these days is bashing keto.”

Not gonna lie, it does feel that way sometimes. 😂
... Speaking of love/hate extremes in – how about that crypto market?

I’m definitely a fan, but I’m perpetually worried that it will eventually get squashed by its chief competitor. (I’ll let you fill in the blank as to who that would be ;) )
... I still fantasize regularly about a “Keto Retreat”. All-you-can-eat low glycemic buffet available 10hr a day. No SAD food for miles, so adherence bolstered. High speed internet, med staff, great accommodations. Kind of a Carb Rehab.

Why doesn’t this exist yet?
... of course, I find I constantly have to re-emphasize that I’m not anti-carb. I’m just anti-Stuff You Have a Problem With.

Many do great on HCLF #PlantBased, for example.

But some have a particular problem with carbs for various reasons be they behavioral, physical, etc
... Speaking of caveating, I really dislike how much I feel the need to do so.

The difficult truth is that we’re in the day and age where people* like to oversimplify what you say, particularly if looking to what you wrote out of context.

*supporters and critics alike
... Oh, and if you see chronically high fasting insulin, you may have a big problem.

I know, I know -- you've probably heard me say that before hundreds of times. But if the repetition was failing then, maybe this will the one time it didn't. 🤞

#TrojanHorse

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More from @DaveKeto

22 May
1/ This new MR study by @mendel_random, @mvholmes, et al makes use of UK Biobank data and determines #ApoB increases risk of #AllCauseMortality, and even #T2Diabetes

This is actually relevant timing as we are rapidly approaching the #LMHRstudy. sciencedirect.com/science/articl…
2/ If you didn't already know, "Lean Mass Hyper-responders" (#LMHRs) would be considered hypercholesterolemic, with this resulting from being very low carb (typically #keto), and are often lean and/or athletic.

(You can read more on this phenotype at CholesterolCode.com/lmhr)
3/ Setting aside why this population exhibits this (see #LipidEnergyModel for more), the most important question is whether they are at risk.

This MR study builds on the existing conventional expectation that they are, and no less in a dose-dependent manner...
Read 6 tweets
18 May
1/ #ListeningThread for @PeterAttiaMD's new podcast with @DrSarahHallberg

Full disclosure, I have tremendous respect for Sarah and all the incredible mountains she has moved in nutrition and health, not to mention just being an incredible human being.

2/ Oh boy -- just 1 minute in and Peter is asking Sarah about dietary fat vs observed composition in vivo! I have a feeling I'm really going to like this episode...
3/ Sarah: "Fatty acids play a critical role, study after study, in cardiovascular risk." -- Love this line...

(Though I'd add a few caveats with regard to lipid profile, but more on that another time)
Read 17 tweets
17 May
1/ Big Update Thread for OwnYourLabs

If you didn't already know, @siobhan_huggins and I launched OwnYourLabs.com last year as a means of ordering private blood work directly. (Feel free to visit the site and for our short intro video)

We have some cool news to share...
2/ In the last few months we've been growing... *a lot*

When we started this originally, it was to help others not only get the labs, but to help encourage them to contribute their anonymized data to help #CitizenScience by given a special discount for opting in (at checkout)...
3/ A few months ago we overhauled the site to include all the features we've been wanting all along (advanced searching/sorting, single page lists, multi-add, bundles, etc)

But even better, checkout is now more streamlined for the anonymous data submission (for those opting in).
Read 7 tweets
24 Apr
1/ Reminder: "Lean Mass Hyper-responder" is literally defined as a combination of LDL ≥ 200, HDL ≥ 80, and Triglycerides ≤ 70.

In other words -- by definition -- #LMHRs are not hypertriglyceridemic (high triglycerides). They are the opposite. (See CholesterolCode.com/lmhr)
2/ For example, in the first of this case series a woman is identified as hypertriglyceridemic (triglycerides of 1109). This is if 15 fold higher than the TG max cap of #LMHR.

lipidjournal.com/article/S1933-…
3/ Moreover, we actually addressed this particular case of hypertriglyceridemia in our Letter to the Editor of this very case series. In fact, it's how we set up the question on what to consider when triglycerides are low instead

Read 4 tweets
17 Apr
1/ It’s ironic, I came across an email I wrote almost 3 years ago when I was first pushing for a “Study on atherosclerosis in LMHRs”. For that first 1.5 years I tried to raise interest and money from inside the system. Some of these details I’ll go into with the book eventually..
2/ Not at all calling anyone out — just noting that it took me a while to realize it was likely a dead end.

For almost all of them, the answer to this question was already known: High LDL LMHR = high atherosclerosis

(And FWIW, it’s possible they’re right— we’ll soon see...)
3/ Then I had the crazy idea to start a charity and announce at #LowCarbHouston in Oct 2019 that we’re going to just try to straight up raise the money to do this study through crowdfunding.

And you know what?

The community stepped up.
Read 4 tweets
15 Apr
I saw this paper linked by @BioLayne (hat tip!) in a twitter discussion and had to stop and read most of it. Basically SFA vs PUFA infused muffin RCT. There's quite a lot of interesting data within. And it's publicly available, btw (no firewall)...

ncbi.nlm.nih.gov/pmc/articles/P…
... The lipid profile changes for the SFA group are unsurprising to me, ofc. But I was surprised they went with ALT as the proxy for "liver fat accumulation". Relative change 53%, but I didn't find the absolute values listed for ALT between groups? Maybe in the supplement...?
... They had a subgroup of 10 (5 of each) where the did PET-MRIs (need more of this in studies) to detect "change in hepatic palmitate uptake" -- which tends to be a stronger proxy for liver fat accumulation, but it showed no association.
Read 4 tweets

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