Thread by @Iplaywithgerms

As we learn more about #COVIDvaccine #immune response in people w/ #immunedisorders, remember that not all #immunodeficiencies are created equal. You might see in the news claims about #vaccines not working in the #immunocompromised, but that's not always true. A 🧵

One of the earliest articles showed 15% of #transplant patients were Ab positive after dose 1. This increased to 54% after dose 2, but varied by medications being taken. bit.ly/3x00nyA and bit.ly/3cmfria

In #cancer patients, Ab response varied by type of cancer. Two studies showed 92-95% w/ solid tumors were Ab pos after the 2nd dose. One showed only 60% w/ hematological cancers were positive. bit.ly/34LseXc (both) bit.ly/3chrU6s (solid tumor only)

We also have inborn errors of immunity (#primaryimmunodeficiency). There are over 400 distinct disorders caused by mutations in the genome in places that affect the immune response. Raise your hand if you think they'll all have the same vaccine response. bit.ly/3uTFxzh

In this population, it is dependent on which mutation, medications received (i.e. immunoglobulin replacement therapy) and the frequency of treatment, stem cell transplant status, etc. Two small studies have been published on Ab response:

One had 11 patients: 10/11 had an Ab response! Only 2/10 had noticeable immune suppression though and 8 received replacement Ig. bit.ly/3pz4f7j The 2nd had 26 ppl, most w/ Ab deficiency. 22/26 had replacement Ig, 18/26 were Ab pos. bit.ly/2TJF4mz

There's still so much we don't know about the #immuneresponse to #COVID19 #vaccines in people with #immunedisorders. But one thing we DO know is that we can't assume they're all equal. Hope this helped! Stay safe everyone!