Discover and read the best of Twitter Threads about #transplant

Most recents (24)

Warning ⚠️ ⛔️ : Uncomfortable Thread 🪡
My tweets lately have focused on my daughter’s #healthcare at @SanfordHealth & our struggle to access appropriate & compassion care where her agency is not taken away. I know the threads my be uncomfortable for some particularly if you 1
are a #medical professional. I am aware that many are thinking 💭‘what’s the back story’, ‘something they did caused this no #medical facility or #medical #professional would partake in this’. I get that. There IS a back story. A child at 2 wks having her 1st #hereditary 2
#pancreatitis flare. In 1st grade undergoing her 1st #transplant. In 6th grade undergoing 2nd #transplant. Complications, no real follow up. Complications being ignored. Physicians both on #transplant team as well as others questioning her symptoms, her #pain. Dismissing & 3
Read 18 tweets
My hero mom successfully donated one of her kidneys to my dad @NM_Transplant last week! As a family with Polycystic Kidney Disease @PKDFoundation we have prepared for this for decades since my grandpa was diagnosed and transplanted in 2001. 🧵 Image
As a 7-year old, I remember feeling so confused that someone else’s kidney was functioning in my grandpa. Fast forward to pharmacy school @UIPharmacy when I learned of the immense impact a transplant pharmacist could have on the transplant process.
Close monitoring of immunosuppression, patient and family counseling, and participation in transplant selection committees - all pushed me to pursue a career in clinical pharmacy. I wanted to help families like mine through this process.
Read 14 tweets
#heart #transplant #covid19 #vaccination There is a great deal of consternation about heart transplants and vaccine requirements. This thread is meant to explain to the public why our partners in heart transplant are so incredibly strict.
Heart transplant is one of the most scarce resources that exist. Big reason? A donor has to be deceased for a heart to be available. Even then, a separate medical team has to be sure the heart is healthy enough survive two surgeries (leaving the donor, getting to destination).
If fully functional hearts could be delivered at some point in the far future on a 3d printer, this will no longer be an issue. That’s an active area of research but not a reality.
Read 7 tweets
#Surveillance must be done in a population with high risk of that disease. Nevertheless, patients at the higher end of the spectrum (e.g., cirrhosis with Child-Pugh C) carry a restricted #prognosis even with radical therapies. @EleanorBarnesOx @CR_UK @NIHRresearch 1/7
Cirrhotic patients with advanced liver failure or Child-Pugh B with #decompensation are usually not screened for HCC because they could not tolerate effective therapies. This changes if they are listed for transplant, however. 2/7
HCC onset can trigger changes in priority on the list as well as lend someone ineligible for #transplant. It is important, therefore, to maintain surveillance of HCC for this population. 3/7
Read 7 tweets
Od jakiegoś czasu głośno jest o słowach Justyny Sochy namawiających ludzi do składania oświadczeń do Centralnego Rejestru Sprzeciwów, działającego przy @Poltransplant, chcielibyśmy w związku z tym nieco opowiedzieć o procedurach związanych ze stwierdzaniem śmierci mózgu
u potencjalnego dawcy narządów. Proces ten jest żmudny i na wielu etapach zabezpieczony przed pomyłkami. Po pierwsze, u pacjenta musi wystąpić tzw. arefleksja pniowa, to znaczy zanik odruchów kaszlu i wymiotnego, oraz wystąpić rozszerzenie źrenic i brak reakcji na światło
Stwierdzenia tego może dokonać nawet lekarz nieposiadający specjalizacji. Fakt stwierdzenia arefleksji pniowej oznacza w odpowiednim Protokole Postępowania Diagnostycznego Śmierci Mózgu. P
Read 14 tweets
An Israeli biotech company, Renewal Bio that recently created mouse embryos using stem cells, has announced plans to make human embryos to harvest tissue for organ transplants and anti-aging procedures.

#Stemcells #biotech #biology #Syntheticbiology #Aging #transplant
The scientist behind the work clarified that:
The synthetic embryos were not "real" embryos and did not have the potential to develop into live animals. But that is partly because they don't have the technology, right now, to do so.
He admits to taking his "ground-breaking" technology to the next level and creating human embryos. The purpose is to harvest tissue to be used in transplant treatments meant to lengthen a person's life and health.
Read 5 tweets
Bell Media Confirms 2022/23 Original Programming Slate of Nearly 100 Titles, Boasting 973 Hours of English and French-Language Content. Visit @thelede_ca for more info and assets. #BellMediaUpfront
Coming to @CTV from #TheOffice’s @aqfarrell and @CounterfeitPics, #Shelved is an original single-camera work-place comedy centered around the employees and patrons at the Jameson Public Library in Parkdale. For more info visit @thelede_ca #BellMediaUpfront
Recently announced @CTV Original drama, #SullivansCrossing begins production this summer, with @MorganKohan, @ChadMMurray, @ScottGPatterson set to star. For more info on Bell Media Original Programming, visit @thelede_ca #BellMediaUpfront
Read 18 tweets
1/Hello everyone! Welcome to this month’s #ASPNFOAM group Tweetorial, featuring BK polyomavirus (BKV) & #BKNephropathy
🚨Spoiler alert: BK does not stand for Burger King🍔. But hopefully this 🧵 has been cooked up to your liking😉.
#Medtwitter #NephTwitter #PedNeph @ASPNeph
2.1/ So what’s “BK” & why can’t you have it with a side of🍟?
“BK” actually stands for B.K., the initials of the Sudanese🇸🇩 kidney transplant (KT) patient in whom the virus was 1st identified back in 1971! Not that long ago if you think about it 🤔
(PMID: 4104714, 33319201)
➤BKV is a non-enveloped double-strand DNA virus.
➤Primary infection occurs through respiratory secretions, mainly asymptomatic.
➤It infects urothelial and tubular cells in a non-replicative latent phase.
Read 35 tweets
#OutBreak of acute #hepatitis among #children
650 probable cases of acute hepatitis of unknown
aetiology in children have been reported to WHO from 33 countries in 5 WHO Regions between 5 April and 26 May 2022.
1/… Image
- Three quarters (75.4%) of cases are 5 years of age.

- Of 156 cases with information on hospital admission, 22 (14.1%) were admitted to an intensive care unit.

Of the 117 cases for which this information was available, 14 (12%) have received a liver #transplant.
- Overall, 181 cases were tested for #adenovirus by any specimen type, of which 110 (60.8%) tested positive. The positivity rate was the highest in whole blood specimens (69.5%).

Table. Classification of reported probable cases per country Image
Read 7 tweets
🧵 Question Abt: Transplantation and Fetal Toxicity of Immunosuppressive Drugs in Pregnancy. 1/13 #Access #ProLife #prochoice #SCT #AbortionBan #healthcare
Q: What is the medical safety net for premenopausal women that are also transplant recipients who MUST take multiple immunosuppressive drugs? 2/13

#Access #ProLife #prochoice #SCT #AbortionBan #healthcare
She can’t depend on the #pill to prevent an unwanted #pregnancy because of daily antibiotics. 3/13

#Access #ProLife #prochoice #SCT #AbortionBan #healthcare
Read 14 tweets
🧵 In the US, until recently, your chances of receiving a donated #liver w/in 30 days would vary significantly depending on where you lived—as low as 1%, or as high as 60%. Remember Steve Jobs' speedy liver transplant? He got on multiple waitlists...🧵…
For decades, experts and providers have been pressing for a more equitable system of organ allocation, one that would even the odds between, say, a patient in a dense urban center with a long waitlist and a patient in a more rural, statistically healthier area with a short one.
For almost 50 years, the system in place was an outgrowth of informal sharing networks between doctors and medical centers, resulting in a web of organ procurement organizations (OPOs) and donation service areas (DSAs) spread out across the country. #donatelife
Read 8 tweets
Good morning followers, new and not-new! After the flux of newcomers this weekend, I thought I’d introduce a little bit more about me + my journey so far to becoming a scientific/data illustrator. Read within! ⬇️🧵🪞🔬👨🏻‍🎓 #bio #aboutme #art #artist #scientificillustration #sciart Portrait of MarkIllustrated banner for Mark...Illustrated banner for Mark...
My name's Mark and I am super passionate about telling science stories with the power of visual media🎨 I love illustration, I learn best with visuals, and I am constantly looking for (er, doodling?) ways to make pictures say MORE than just "a thousand words” 😉 Introductory portrait of Ma...Showcase of various example...5 icons in the center of th...Picture of Mark drawing on ...
I've always been drawn to art as a kid. Ever since I could hold a pencil, I've been creatively engaged. Growing up I was discouraged from pursuing art (who wasn't?) and so I gradually developed an interest in science. Natural History is my favourite subject. 🌐🪱🐒🦀🦩🍄🪸🪐✨
Read 16 tweets
#pigtransplant #Transplant
Dr. Mohammed Mansoor Mohiuddin’s efforts finally paid off on January 7, when his team at the University of Maryland School of Medicine successfully transplanted the heart of a genetically modified pig into a man suffering from a severe heart ailment.
“It was my dream, which came true. It’s something I didn’t imagine doing in my lifetime,” Mohiuddin, who is the director of the Cardiac Xenotransplantation Programme at the university, tells TRT World.
Read 4 tweets
My sincerest & humblest apologies all! For the first time in my life, ever, 9pm, Christmas Eve & i actually just realised what day it was! 😱⚠️
No, i have no idea either but i guess that's what 2 years of near isolation can do to you (throw in painkillers, CF, fibro & depression)
Never assume that because you don't hear from someone everything is ok (the old, "no news is good news" {as all must be ok!}, they're just busy! Especially when it's such a landmark day & ppl are invariably wrapped up with their families. That's not always the case!
Why am i isolating at Christmas? 2 reasons:
🔵 many NHS staff appear to be falling ill despite being triple jabbed &
🔵 Studies seem to be showing effectiveness behind to wane a bit after 10 weeks.

So do you go meet your elderly mum, who's allowing my nephew to shuttle between..
Read 10 tweets
🧵1/5 #UKchildren 💔I’ve lost track the number of times this kind of “but…”argument is used where (all ages) covid death figures are concerned- but they were old, but they had serious health problems, but they were obese… it feeds down the flow chart of u can ignore covid b’cos
..2/ at the results end of the flow chart we have personal choice trumps severe health risks, eugenics, getting told to f-off on SM when raising issues for CEV community, valid concerns dismissed as hysteria or anxiety, stay indoors & keep the hazmat suit on etc etc….
3/ the longer covid drags on thanks to these ignorant, hurtful,discriminatory takes, the gloomier the outlook gets, yet doom & gloom is what those wanting to suppress covid were accused of. Having #asthma, #chemotherapy #transplant pt, etc your risks are waaayyy higher
Read 5 tweets
👻 AKI in patients with a kidney transplant can sometimes be “SCARI”

🧵Let’s talk about an approach I recently learned to some common causes of late (>3 months) allograft dysfunction to overcome the fear together #Tweetorial #NephTwitter
🎃 Allograft dysfunction is defined by a rise in serum Cr of approximately 25%

🎃 It is often asymptomatic, identified on routine blood work

🎃 It can also present with nonspecific symptoms such as nausea, vomiting or diarrhea.
Let's start with a not-so-SCARI case!

👨🏽 50 y/o M with ESKD due to DM2 s/p deceased donor kidney transplant 5 yrs ago

🧪 Cr 2.0 (176 umol/L) baseline Cr 1.3 (115 umol/L). No change in urinary frequency, amount or color. No recent illness

What kidney imaging do you suggest?
Read 21 tweets
Thread: Thoughts on #valuebased & #patientcenteredcare

Within #healthcare & #advocacy there seems to be a great deal of discussion on both #valuebased care & #PCC. #Healthcare costs have skyrocketed’ & thus a need to #reduce. I am not an #economist but as a #caregiver I 1/
definitely have seen ‘waste’. From my POV costs will continue to skyrocket even if #valuebased care is implemented. One reason (again not an economist) is the vulture ‘istic’ aspect of industries profiting from our system. The other reason is that our system is not centered 2/
around the #patient or patients needs. Thus, if the value based metric is reduced hospital admissions, this, on the face seems straight forth, however if the patients needs are not taken into account but only focused on established metric, costs could (& I will argue often r) 3/
Read 14 tweets
1/ Serious End-of-Life 🧵

…He told her, “Never give up on me because I’ll keep fighting to live.” What does it mean when a person valiantly asks this of a spouse & then illness leads to #transplant, #infection, and eventually #life support that doesn’t help?
2/ First I just listened to her heartache and saw their immense love. “I made a #promise, Doctor.” My personal commitment became to help this couple uphold that promise, yet medical options had long since run out & failed him. I asked her to come into the hall.
3/ Always go out outside a pt’s room to discuss anything you don’t want the patient to hear, even when he is in a dense coma. Assume dying pts hear everything said & respect their dignity as your number one goal in all interactions. Here is what I said…
Read 10 tweets
As we learn more about #COVIDvaccine #immune response in people w/ #immunedisorders, remember that not all #immunodeficiencies are created equal. You might see in the news claims about #vaccines not working in the #immunocompromised, but that's not always true. A 🧵
One of the earliest articles showed 15% of #transplant patients were Ab positive after dose 1. This increased to 54% after dose 2, but varied by medications being taken. and
In #cancer patients, Ab response varied by type of cancer. Two studies showed 92-95% w/ solid tumors were Ab pos after the 2nd dose. One showed only 60% w/ hematological cancers were positive. (both) (solid tumor only)
Read 7 tweets
1/A horrific patient scene today. A #kidney #transplant patient doing well since 2015. Had fall and fracture of foot. Underwent surgery,improving. Asked for physio sessions to continue at home. Asks around,finds #ayurvedic traditional healer. He does external works.
2/ patient feels better. #Ayurveda healer gets his trust. Says post transplant infections and diabetes worsen (patient was already diabetic kidney disease for which transplant was done). Says #natural is safest way. Patient falls for healers confidence. Starts #herbal drugs.
3/ Drugs and potions prepared at home from locally sourced plants. Small fee Healer also advise nutritional changes. More like starvation. No proteins. Remember patient is post kidney transplant. #weightloss in 1 mo. Loss of appetite in 2 months. Then came something unexpected.
Read 9 tweets
Delighted to share a new study from our lab on the role of gut commensal fungi mycobiota in shaping the human protective IgG antibody repertoire @CellCellPress…
During immunosuppression ( organ #Transplant #chemotherapy ) or in diseases such as #IBD #crohnsdisease, gut #mycobiota can turn into a “reservoir” of pathogens, BUT most people live peacefully with their fungi. Do they benefit from them? Do fungi benefit form us? Neutral rl.?
Fungi are considered a minor component of the gut #microbiome ( less than 0.1% of genetic material in feces), but we found that fungal biomass in the healthy human gut makes considerably more: up to 2%.
Read 13 tweets
#ToughTxCase I am going to start an educational series for #transplant professionals/trainees on complex cases I have the privilege to see @UWHealth Patients have provided informed consent for us to discuss their condition in order to help other similar cases @uw_nephrology
#ToughTxCase #1 is the story of Tom, a 73 year old man, who received a living unrelated #kidney tx for #ESRD due to an unknown etiology. Low immunological risk, VXM (-), #CMV D+/R-, basiliximab induction, standard TAC/MPA/P maintenance Rx on Valgan prophylaxis x 6M @TxPharmD
At his 3M visit, Tom complains of #diarrhea, weight loss (4 lbs in 1 month) and poor energy. His kidney fxn is at baseline Scr 1.3 mg/dL. What is the most likely diagnosis? Please feel free to discuss! @uw_IMresidency @askrenal @Nephro_Sparks
Read 35 tweets
My attempt on "Decoding the HLA" with tweetorial & some slides/VisualArts @kidney_boy @NSMCInternship @Nephro_Sparks @hswapnil @rheault_m @RenalFellowNtwk @ssfarouk #Transplant
💥MHC complex
⚡️cluster of genes--> encodes HLA molecules
⚡️located on chromosome 6p21
⚡️over 200 genes; of which 40% involved in immune response
💥HLA Genes:
⚡️main function is immune regulation
⚡️major barrier to transplant
⚡️gene products are histocompatibility molecules
⚡️highly polymorphic
⚡️significant linkage disequilibrium 👇
Read 18 tweets
#crazy Useless #patient

Middle-aged man, loves his #family, #farming, drives a cab, #happy. Son & wife at #home. Father-son relationship strong as rock. One #morning, son finds father mumbling to self. Mother says he hardly slept
Mumbling becomes angry ramblings. #Clinical LAENNEC WAS TAUGHT THE IMPO...
Has very little #breakfast. Walks excessively. Goes and lies down, only to get up and walk again. Family interactions little. Sleeps well for 2 hours from 12 to 2PM. Lunchtime. Groggy #father gets on the lunch table and defecates near plates and food. Son and mother aghast.
Father has gone mad. Calls the friendly neighbor, brings his car, rushes to #Medical specialty #clinic nearby. Father disoriented. Son gets the Fword from his own father multiple times, he is shocked! Then comes hurling of abuses after which they restrain him in the car.
Read 15 tweets

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