This is a very late #WeekendLecture
but you can review it anytime you want😉
🧠#Aneurysm & #Subarachnoid Hemorrhage
Unruptured intracranial aneurysms are pathologic dilations at major branching brain arteries
~3% of adult population
nejm.org/doi/full/10.10…
thelancet.com/journals/lance… Image
#WeekendLecture
#Aneurysms & #SAH
The most common presentation of intracranial aneurysm is rupture leading to #SAH
The risk of rupture depends on patient and aneurysm related factor, ie: age/gender/location/size/growth, etc
🧠ahajournals.org/doi/10.1161/ST…
🧠journals.lww.com/continuum/Abst… Image
#WeekendLecture
#Aneurysms & #SAH
It is well known that endovascular or neurosurgical management of #unruptured intracranial aneurysm is not free of procedural #complications
This study investigates risk factors for this complications @JAMANeuro
👇
jamanetwork.com/journals/jaman… ImageImage
#WeekendLecture
#Aneurysms & #SAH
The hallmark presenting symptom of #aSAH is “the worst headache of my life”
The onset is sudden, headache is severe and reaches maximal intensity in seconds👉 #thunderclap headache
@NEJM check the interactive graphic⤵️
nejm.org/doi/full/10.10… Image
#WeekendLecture
#Aneurysms & #SAH
#NCCT is the 1st #diagnostic test
If CT is (-), next step should be lumbar puncture
If imaged on 3rd-gen CT, < 6h of onset in a neurologically intact pt & interpreted as normal by a neurorx, SAH is r/o and no further investigations are necessary Image
#WeekendLecture
#Aneurysms & #SAH
The strategies to minimize brain damage after #aSAH:
-⏬acute 🧠injury and #ICP:
👉hydrocephalus
👉🧠edema
-Prevent #rebleeding
-Minimize delayed ischemia #DCI, from #vasospasm and other factors

sciencedirect.com/science/articl… Image
#WeekendLecture
#Aneurysms & #SAH
Preventing #rebleeding (~13%)may be achieved by treating acute HTN, #repairing the aneurysm as soon as possible, and maybe administering #antifibrinolytic drugs
#ULTRA early tranexamic acid trial did not improve 6m mRS 😕
thelancet.com/journals/lance…
#WeekendLecture
#Aneurysms & #SAH
We have learned that #aSAH is not just an intracranial disease
Early brain injury can induce #cardiac disfunction an #pulmonary edema
#Neurocritical care aims for this global approach

nature.com/articles/nrneu… ImageImage

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with WorldStrokeAcademy

WorldStrokeAcademy Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @WorldStrokeEd

1 Aug
#WeekendLecture
#PregnancyAndStroke

#Pregnancy and #puerperium confer an ⬆️ risk for ischemic as well as hemorrhagic stroke, with incidence rates being 3-fold higher as compared with nonpregnant women

👉doi.org/10.1016/j.ncl.…

a short 🧵 Image
#WeekendLecture
#PregnancyAndStroke

@DrRickSwartz @patrice_lindsay et al metaanalysis
👉11 studies
👉>85 million #pregnancy and #postpartum admissions in various countries
👉overall incidence of #stroke was 30 per 100,000 hospitalizations👈
@IntJStroke

journals.sagepub.com/doi/10.1177/17… ImageImage
#WeekendLecture
#PregnancyAndStroke
RFs:
☑️Age, >40yo OR3.1
☑️Race/ethnicity
☑️Migraine, thrombophilia, SLE, 🫀disease, HTN, thrombocytopenia, diabetes
☑️Pregnancy complications
✅For hemorrhagic stroke: aneurysms, AVM, Hypertensive Disorders of Pregnancy

journals.lww.com/greenjournal/F… ImageImage
Read 12 tweets
18 Jul
#WeekendLecture
#CerebralMicrobleeds #CMB

Radiological construct: small (2–10 mm diameter) round or ovoid #hypointense foci with associated #blooming with enhanced visibility on #MRI sequences sensitive to #susceptibility effects

thelancet.com/journals/laneu… ImageImage
#WeekendLecture
#CMB
🔬#Pathology: recent or old microhaemorrhages
🩸Microvessel injuries, ie: dilatation/fragmentation of the wall, amyloid-ß (in CAA) and fibrin extravasation
🩸Extravasation of red blood cells
🩸#hemosiderin-laden macrophages
karger.com/Article/FullTe… ImageImage
#WeekendLecture

In daily practice #CMB represents a radiological marker of #small vessel disease

In general:
🩸Strictly #lobar CMBs👉CAA
🩸Strictly #deep👉hypertension-related SVD ie #arteriolosclerosis
🩸Mixed 👉combination👆, but must think #hereditary #SVD, ie #CADASIL Image
Read 8 tweets
4 Jul
#WeekendLecture
#ESUS
In most studies ~25% of ischemic stroke are classified as #cryptogenic
In 2014 the Embolic Stroke of Undetermined Source clinical construct was introduced, as a subset from cryptogenics
Criteria & diagnostic assessment were proposed

thelancet.com/journals/laneu… ImageImage
#WeekendLecture
#ESUS

Although a long list of causes was described, covert AF was conceived as perhaps the most important underlying mechanism
It was hypothesized that oral #anticoagulation may⏬ the risk of stroke recurence in #ESUS Image
#WeekendLecture
#ESUS

A systematic review in 2017 (from several authors of the pivotal paper) showed:
👉Frequency: 17% (9-25%) of IS
👉Mean age: 65
👉Recurrence: 4.5% per year
👉Younger, lower freq of vascular RFs and milder stroke vs non-ESUS IS

ahajournals.org/doi/10.1161/st… Image
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

:(