#location location location: thrilled to share our work @CellCellPress! #interferons dictate #COVID19 severity! Specific #IFNs are produced along the #airways in response to #SARSCoV2 and drive protective or detrimental #transcriptional programs! 1/7 doi.org/10.1016/j.cell…
IFNs are driven by high #viral #loads, suggesting that viral recognition is only achieved when #SARSCoV2 reaches a certain threshold! Efficient induction of protective IFNs is preferentially achieved by younger patients, further explaining susceptibility of elders to #COVID19 2/7
#IFNL1 & #IFNL3 characterize mild illness & drive potent anti-#SARSCoV2 #ISGs in the upper #airways. Severe patients show #typeI IFN & #IFNL2 along the respiratory tract but lack ISGs, dampen cell proliferation programs associated to #repair and boost #apoptotic #p53 pathways 3/7
IFNL1 is the most efficient #typeIII IFN to drive #antiviral ISGs. #lung #epithelial cells efficiently produce IFNL1 in response to #SARSCoV2 & #RIG-I or #TLR3. #cDCs instead use #TLR3 to produce #IFNL2,3 by recognizing #dsRNA or #DAMPs released by infected epithelial cells 4/7
In agreement with #transcriptional analyses recently published with @TheBrysonLab, we found no relationship between #protein levels of #IFNs or other #inflammatory mediators present in the #lungs or in the #blood of #COVID19 #patients! doi.org/10.1016/j.isci… 5/7
This is an incredible team effort @harvardmed @BostonChildrens @Harvard led by super talented #phdstudent @BennieSposito & brand new #newPI @achillebro + Nicasio Mancini’s team @SanRaffaeleMI @MyUniSR + many friends & colleagues in 🇮🇹 & 🇬🇧 + our #patients + support @BWFUND 6/7
Finally sincere THANKS 🙏 to: i) #reviewers & #editors @CellPressNews for their tough but always fair comments that pushed the original @biorxivpreprint to the next level; ii) to all the mice in our @ScienceMagazine paper that allowed this human study doi.org/10.1126/scienc… 7/7
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