1/n So, what do I think, as a non-expert, son to holocaust survivors, about @VPrasadMDMPH's article, claiming #COVID19 restrictions could be used as blueprint for a future totalitarian regime, his analogy to Hitler's rise in Germany. @GYamey says it better
2/n Frankly, not much. My approach is, if you want to understand threats to democracy go to experts (I am not, @VPrasadMDMPH is DEFINITELY NOT) there are really good books, like @TimothyDSnyder's #OnTyranny. Check out this clip
6/n Don't forget (this is not ad-hominem @VPrasadMDMPH, but a simple truth) the claim that public health measures promote tyranny is key to the attack by those who wish to undermine democracy, support authoritarians @PeterHotez said it better
7/n As a Jew, son to holocaust survivors, student of Europe between Hitler & Stalin (h/t @TimothyDSnyder), I always see a bigger threat in those that accept death/disease among the poor & old, than in those that protect them. But I accept @GYamey's call & will not go there. Fin.
1/n This thread is not about Medicine, Science or Lung Disease. It’s about what you should ask when when you hear about another cycle of violence in #IsraelPalestine. Written in #Solidarity with the Jews & Arabs who today stand together against racism & hate #TrueHeroes
2/n When people speak about “country x’s right to defend itself” - what you should ask, does the leadership of country x have the right to provoke violence? and do the actions taken really constitute defense or serve another agenda? #KnowWhatToAsk#IsraelPalestine
3/n When they say but “look at the violence in the streets by the minority ” - what you should ask, is what has been done to the minority , how many have been dispossessed, killed without recourse, disenfranchised and for how long? #IsraelPalestine#EndTheOppression
1/n Usually we invite friends/colleagues to our SEDER, but no guests last & this year. Inspired by FB comment by @gregggonsalves I thought it’d be fun to share our dishes with #MedTwitter friends as if we’re together - see following thread #PCCMEats#HappyPassover2021
2/n Every item on the Seder Plate has a symbolic meaning in the ceremonial retelling of the Exodus story - except the Orange, a recent addition dedicated to #inclusion of those marginalized in traditional religions (women, LGBTQ) #NKsSederTweetorial#PCCMEats#HappyPassover2021
3/n The bitter & spicy taste of horseradish, fresh taste of greens & Sweet & earthy look of Harosset all symbolize aspects of the story - but biggest mystery is how well they fit together in a Matzah sandwich - or is it not? #NKsSederTweetorial#PCCMEats#HappyPassover2021
2/n As expected, type-1 IFN signature dominates all cell types (with a uniquely IFN-activated CD8 T cell cluster). The signature correlates strongly with initial viral load and in repeated samples with time #COVID19#Covid19CellAtlasmedrxiv.org/content/10.110…
3/n A skewed immunopralysis like anti-inflammatory signature is found in monocytes of #COVID19 progressive patients, connectome analysis suggested disrupted connectivity between LAG3 and MHC signalling medrxiv.org/content/10.110…
2/n Among epithelial cells, we identified cells DISTINCT from ANY epithelial cells previously described in human lungs. These aberrant basaloid cells are at the edge of myofibroblast foci & express fibrotic molecules & regulators #IPFCellAtlas#CureIPFadvances.sciencemag.org/content/6/28/e…
3/n Among enodthelial cells we discovered a previously undescribed population of COL15A1+ CD31+ cells. They are usually restricted to the airway but in IPF are found in the lung parenchyma - what are they doing there? #IPFCellAtlas#scRNAseq#CureIPFadvances.sciencemag.org/content/6/28/e…
1/n Dr. Mark Siegel is a superb critical care physician, ethicist & legendary Internal Medicine Residency Program Director whose weekly notes I read eagerly. This week’s note is titled “what I’d say to new interns” #MarksWisdom#TipsForNewDocs#MedEd facebook.com/1444114056/pos…
2/n Siegel starts saying #COVID19 took away joys of orientation: pizza, hot dogs, cold beer, gelato, unscripted conversations & new friendships. But don’t worry, show up, work hard, don't worry, you'll do great & then follows with 14 SPECIFIC TIPS: #MarksWisdom#TipsForNewDocs
3/n Tip #1: Take your own histories. Charts are rife with inaccurate, missing information. Key exposures, mounting symptoms, details patients held back- until you asked. To paraphrase Osler, patients will tell you the diagnosis, if you listen. #MarksWisdom#TipsForNewDocs#MedEd
1/n This is a thread about microRNA therapeutics in pulmonary fibrosis summarizing the MiRagen call today - we've been collaborating for >6 years now through an NIH-NHLBI funded CADET II grant to develop mir-29 as a therapy - the progress is amazing! #CureIPF#Mir29
3/n Rusty Montgomery @rmontonio of MiRagen: The Mir-29 mimic Remlarsen has hit fibrosis targets in a phase 1 trial of Keloid formation - a phase II trial is happening #AntiKeloid#CureScarring