February 15 and August 15, 2021 C19 Vaccination during Pregnancy & First-Trimester Miscarriage
compares to
March 2019 Norway study.

#percentage doesn't fit. #covid & #COVIDVaccination era has more miscarriages.

March 2019 Norway study:
March 2019 norway study
file:///C:/Users/User/Downloads/Role_of_maternal_age_and_pregnancy_history_in_risk.pdf
#covid #Covidvaccine era in Norway Feb 2021-Aug 2021
nejm.org/doi/full/10.10…
March 2019 study Participants : All Norwegian women that were pregnant between
2009-13.

Feb2021-Aug2021 study participants: all women who were registered between Feb15 and Aug15, 2021, as having had a miscarriage before 14 weeks of gestation (case patients) and those with a
primary care–based confirmation of ongoing pregnancy in the first trimester (controls) in Norway.

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More from @mega_pindang71

9 Nov
Road to #Paxlovid #Pfizer #COVID19 new drug. pubmed.ncbi.nlm.nih.gov/34029993/
3CLpro inhibitors commonly target host proteases, which presents a potential liability for unexpected side effects.
Challenges : enzyme inhibition was only achieved in the absence of physiologically relevant reducing agents, and the reported antiviral effect in cells infected with SARS-CoV-2 could not be reproduced and was therefore suspected to be an indirect consequence of cell death.
Additional challenges in assessing 3CLpro inhibition potency in infected cells arose from the role of host proteases in virus entry. SARSCoV-2 uses human ACE2 as its entry receptor and human proteases as entry activators including cell surface transmembrane protease/serine
Read 8 tweets
9 Nov
The Road to Paxlovid (PF-07321332)
A thread. #paxlovid #protease #inhibitors #ivermectin #COVID19
Dr. John Campbell: Paxlovid vs Ivermectin
New Pfizer antiviral and ivermectin, a pharmacodynamic analysis. Paxlovid (PF-07321332), C₂₃H₃₂F₃N₅O₄
Paxlovid is designed to block the activity of the SARS-CoV-2-3CL protease, an enzyme that the coronavirus needs to replicate. Co-administration with a low dose of
ritonavir helps slow the metabolism, or breakdown, of Paxlovid in order for it to remain active in the body for longer periods of time at higher concentrations to help combat the virus. Paxlovid inhibits viral replication at a stage known as proteolysis, which occurs before
Read 22 tweets
9 Nov
2,433 fetal deaths in VAERS. More fetal deaths in the past 11 months than in the past 30 years.

eventiavversinews.it/2-433-decessi-…
Read 6 tweets
8 Nov
SARS-CoV-2 PL-Pro (Nsp3) Inhibitors.
#nature #plantbased
Salvia miltiorrhiza.

PLpro has an implication in viral invasion by shutting down the viral-induced host innate immune response. Dihydrotanshinone I appears to be the strongest inhibitor amongst the tanshinone ..1/n
derivatives. It is a natural compound isolated from lipophilic fraction of Salvia miltiorrhiza, which has a long history in traditional Chinese medicine. Several derivatives of tanshinones were previously reported to be inhibitors for SARS-CoV-1 PLpro and to a lesser extent ..2/n
in 3CLpro. Dihydrotanshinone I is the best inhibitor of SARS-CoV-2 PLpro and did not inhibit 3CLpro. 3/n
portlandpress.com/biochemj/artic…
Read 6 tweets
8 Nov
SC2 MPro inhibitors alternatives, plant flavonoids.
1/n
#MPro #SARSCoV2 #inhibitor
Kaempferol, Quercetin, and Rutin
were able to bind at the substrate binding pocket of 3CLpro with high affinity and interact with the active site residues ..
chemrxiv.org/engage/chemrxi…
such as His41 and Cys145 through hydrogen bonding and hydrophobic interactions. In fact, the binding affinity of Rutin was much higher than Chloroquine (1000 times) and Hydroxychloroquine (100 times) and was comparable to that of the reference drug Remdesivir. 2/n
The results suggest that natural compounds such as flavonoids have the potential to be developed as novel inhibitors of SARS-CoV-2. 3/n
Read 12 tweets
8 Nov
In silico identification of natural products from Centella asiatica as SARS-COV-2 main protease (M pro) inhibitor. 1/n

❌❌❌ #ritonavir #molnupiravir in #COVID19
No more #tryglyceride #mutagenesis

pubmed.ncbi.nlm.nih.gov/34345605/
2/n
Anti-Inflammatory and anti-vascular leakage effects by combination of Centella asiatica and Vitis vinifera L. (Grapevine) leaf extracts.
#antiinflammatory qualities #anti #vascular #leakage effect

hindawi.com/journals/ecam/…
Read 8 tweets

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