In a world with #Omicron (a rare mutational event), the drug #molnupiravir (a mutagen) was just authorized by the @US_FDA despite:
1⃣ NO estimate of the number of mutations it causes per virus
2⃣ NO estimate of onward viral transmission while on the drug
fda.gov/news-events/pr…
1⃣ NO estimate of the number of mutations it causes per virus
2⃣ NO estimate of onward viral transmission while on the drug
fda.gov/news-events/pr…
@US_FDA Given #molnupiravir's usage to treat #COVID19 is inevitable, what can be done to prevent the potential acceleration of #SARSCoV2 variants?
1⃣patients should strictly ISOLATE WHILE TAKING, especially in the first days on the drug
2⃣ALL DOSES should be taken PRECISELY as directed
1⃣patients should strictly ISOLATE WHILE TAKING, especially in the first days on the drug
2⃣ALL DOSES should be taken PRECISELY as directed
@US_FDA Our own reasons for these recommendations are presented here 👇
https://twitter.com/chasewnelson/status/1465219400064122882
@US_FDA Many others have expressed similar concerns, most recently expounded on here 👇
https://twitter.com/michaelzlin/status/1473818094573441030
@US_FDA Finally, it seems prudent whenever possible to use other treatment options that do not carry a mutational risk. #Paxlovid (a #ProteaseInhibitor) allegedly has much better efficacy, and other drugs like #masitinib and 4′-FlU are close at hand. 👇
https://twitter.com/VirusWhisperer/status/1466543750000177153
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