Daniel J Drucker Profile picture
Dec 31, 2021 8 tweets 11 min read Read on X
In 2021 the world celebrated the 100th anniversary of the discovery of #insulin surely one of the greatest medical breakthroughs of the 20th century #diabetes #T1D @NobelPrize @uoftmedicine academic.oup.com/edrv/article-a…
#EndcrineReviews was pleased to publish a collection of articles devoted to advances #T1D #insulin #diabetes #islets A brief recap, here a comprehensive look at the human islet @powersac_TN @MouseCentral academic.oup.com/edrv/article-a…
A comprehensive deep dive into the human β-cell from autoimmunity to secretory function, proliferation, growth, ER stress and biomarkers. @BruceVerchere @StevenKahn11 academic.oup.com/edrv/article/4…
An updated look at the biology of #exercise #insulin and glucose uptake, from pathophysiology to #epigenetics #T1D #T2D @JuleenRZierath academic.oup.com/edrv/advance-a…
Tremendous advances in the prediction of #T1D beyond antibodies academic.oup.com/edrv/article-a…
Today we take recombinant human protein therapeutics for granted, yet 40 years ago #insulin led the way. How did it happen? A view from a pioneer Arthur Riggs #T1D @genentech @theNASEM academic.oup.com/edrv/article/4…
In 2022, we will celebrate the 100th anniversary of the first #insulin therapy at the Toronto General Hospital @UHN @uoftmedicine @UofT #T1D Look how far we have come but there is still much work to do to improve the lives of PPL with tyoe 1 #diabetes

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Daniel J Drucker

Daniel J Drucker Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @DanielJDrucker

Mar 7
At Capital markets day, @novonordisk highlights the potential of unimolecular amylinR-GLP-1R co-agonism, revealing 13.1% placebo subtracted #weightloss in P 1 12 week data #obesity Image
Some additional granularity on contributions to the primary composite endpoint in the Semaglutide FLOW trial #kidney disease #T2D via @novonordisk Image
@novonordisk A glimpse of P1 efficacy for a GIPR-GLP-1R co-agonist in people with #T2D #weightloss #obesity via @novonordisk P2 planned later in 2024 Image
Read 6 tweets
Jun 4, 2022
GLP-1-based therapies are slowly approaching #bariatricsurgery level #weightloss and more exciting science to come. There is the impressive SURMOUNT-1 trial for tirzepatide #obesity nejm.org/doi/full/10.10…
Among the compelling findings, 63% of subjects achieved > 20% #weightloss with 15 mg once weekly Tirzepatide over 72 weeks #obesity nejm.org/doi/full/10.10…
The results obtained with semaglutide and now tirzepatide provide compelling examples of how investments in science over time enable new more effective therapies for metabolic disorders #T2D #Obesity perhaps #NASH. These results also raise the bar for new mechanisms in the space
Read 4 tweets
Jun 8, 2020
For those of you who could not attend the #ENDO2020 sessions this am, due to scheduling or technical challenges, a summary thread #Diabetes #COVID19
We enter the #COVID19 era with an unprecedented set of pharmacological tools that can be used wisely to achieve personalized goals for #T2D
How should we think about the complex interactions between ACE2, DPP4, cardiometabolic inflammation, and the management of #T2D Normally, enhanced ACE2 and reduced DPP4 activity are favorable in PPL with #diabetes
Read 18 tweets
Feb 17, 2020
@AGA_Gastro highlights #NASH #NAFLD first up @VidalPuig Where do the fatty acids go? sciencedirect.com/science/articl…
#NAFLD #NASH How much does the clock matter for pathophysiology or therapeutics #circadian sciencedirect.com/science/articl…
“Lost in Translation” or Utility at Last? NASH biomarkers #genetics and risk prediction beyond PNPLA3 sciencedirect.com/science/articl…
Read 6 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(