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Daniel J Drucker

Dec 31, 2021 • 8 tweets • 11 min read • Read on X

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@NobelPrize

In 2021 the world celebrated the 100th anniversary of the discovery of #insulin surely one of the greatest medical breakthroughs of the 20th century #diabetes #T1D @NobelPrize @uoftmedicine academic.oup.com/edrv/article-a…

@powersac_TN

#EndcrineReviews was pleased to publish a collection of articles devoted to advances #T1D #insulin #diabetes #islets A brief recap, here a comprehensive look at the human islet @powersac_TN @MouseCentral academic.oup.com/edrv/article-a…

@BruceVerchere

A comprehensive deep dive into the human β-cell from autoimmunity to secretory function, proliferation, growth, ER stress and biomarkers. @BruceVerchere @StevenKahn11 academic.oup.com/edrv/article/4…

@JuleenRZierath

An updated look at the biology of #exercise #insulin and glucose uptake, from pathophysiology to #epigenetics #T1D #T2D @JuleenRZierath academic.oup.com/edrv/advance-a…

Tremendous advances in the prediction of #T1D beyond antibodies academic.oup.com/edrv/article-a…

@genentech

Today we take recombinant human protein therapeutics for granted, yet 40 years ago #insulin led the way. How did it happen? A view from a pioneer Arthur Riggs #T1D @genentech @theNASEM academic.oup.com/edrv/article/4…

@UHN

In 2022, we will celebrate the 100th anniversary of the first #insulin therapy at the Toronto General Hospital @UHN @uoftmedicine @UofT #T1D Look how far we have come but there is still much work to do to improve the lives of PPL with tyoe 1 #diabetes

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More from @DanielJDrucker

Daniel J Drucker

@DanielJDrucker

Mar 7

At Capital markets day, @novonordisk highlights the potential of unimolecular amylinR-GLP-1R co-agonism, revealing 13.1% placebo subtracted #weightloss in P 1 12 week data #obesity

Some additional granularity on contributions to the primary composite endpoint in the Semaglutide FLOW trial #kidney disease #T2D via @novonordisk

@novonordisk A glimpse of P1 efficacy for a GIPR-GLP-1R co-agonist in people with #T2D #weightloss #obesity via @novonordisk P2 planned later in 2024

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Daniel J Drucker

@DanielJDrucker

Jun 4, 2022

GLP-1-based therapies are slowly approaching #bariatricsurgery level #weightloss and more exciting science to come. There is the impressive SURMOUNT-1 trial for tirzepatide #obesity nejm.org/doi/full/10.10…

Among the compelling findings, 63% of subjects achieved > 20% #weightloss with 15 mg once weekly Tirzepatide over 72 weeks #obesity nejm.org/doi/full/10.10…

The results obtained with semaglutide and now tirzepatide provide compelling examples of how investments in science over time enable new more effective therapies for metabolic disorders #T2D #Obesity perhaps #NASH. These results also raise the bar for new mechanisms in the space

Read 4 tweets

Daniel J Drucker

@DanielJDrucker

Jun 8, 2020

For those of you who could not attend the #ENDO2020 sessions this am, due to scheduling or technical challenges, a summary thread #Diabetes #COVID19

We enter the #COVID19 era with an unprecedented set of pharmacological tools that can be used wisely to achieve personalized goals for #T2D

How should we think about the complex interactions between ACE2, DPP4, cardiometabolic inflammation, and the management of #T2D Normally, enhanced ACE2 and reduced DPP4 activity are favorable in PPL with #diabetes

Read 18 tweets