Unprecedented case series advances promise of #phage therapy
👇
Phage Therapy of #Mycobacterium Infections: Compassionate-use of Phages in 20 Patients with Drug-Resistant Mycobacterial Disease
1/
academic.oup.com/cid/advance-ar…
@MariadelMarTom
Treatment of Non-tuberculous Mycobacterium could be challenging due to intrinsic antibiotic #resistance. Bacteriophage therapy represents a potentially novel approach.
2/
Phages were administered intravenously, by aerosolization, or both to 20 patients
Favorable clinical or microbiological responses were observed in 11 patients.
3/
Neutralizing antibodies were identified in serum after initiation of phage delivery intravenously in eight patients, potentially contributing to lack of treatment response in four cases but were not consistently associated with unfavorable responses in others.
4/
Favorable clinical outcomes in patients lacking any other treatment options support continued development of adjunctive #phage therapy for some #mycobacterial infections.
5/

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More from @guerreroespejo

Jun 12
Monkeypox virus clearly is endemic in #Nigeria.
Cases occur sporadically throughout the year and across the country except to the far northeast.

#Monkeypox cases continue to occur in Nigeria this year (2022): 110 suspected and 31 confirmed cases
1/
👇
ncdc.gov.ng/diseases/sitre…
The above report does not indicate which of the 2 clades of #MonkeypoxVirus are responsible for the cases.

The reported case fatality rate of 3.6% is higher than the usual 1% for the West African clade but lower than the up to 10% for the Central African clade.
2/

#Nigeria
The report does not indicate if the reported cases are due to person-to-person transmission or to contact with infected wild mammals.

#monkeys are not the reservoirs of the virus, despite the name that the virus has received.
3/
Read 5 tweets
Jun 8
A 26-YO👩‍🦰, sexually active: 1-month of right knee and metacarpal arthralgia, tenosynovitis & pustules on her hand, developed an enlarging chest wall mass.

CT: an abscess on her chest wall, requiring drainage.
1/4

DOI: doi.org/10.1503/cmaj.2…
#IDTwitter #MedEd Image
Urine gonococcal nucleic acid amplification test: ➕ was positive,
16S rRNA with gene sequencing of wall fluid:➕for Neisseria gonorrhoeae.

DISSEMINATED GONOCOCCAL INFECTION

Ceftriaxone IV stopped after the abscess had resolved
2/4

#MedicalStudents #microbiology
Neisseria gonorrhoeae is transmitted mainly through unprotected vaginal, anal and oral intercourse
3/4

#MedTwitter #MedStudentTwitter
Read 4 tweets
Jun 7
Lactante 4 meses, dermatitis atópica, su hermana con laringitis aguda: erupción papulosa de evolución a costras en 1 día, predominando sobre placas de eccema preexistentes.

Se inician en el tronco, incluyen cabeza, área del pañal y vesículas en boca.
1/5

#pediatria #Pediatrics
PCR (para herpesvirus y enterovirus):➕para enterovirus Coxsackie A6

ECCEMA COXSAKIUM

El A6 produce también: erupción vesículo-bullosa erosiva, cuadro Gianotti-Crosti-like y rash purpúrico-petequial

✒️Martín A y col continuum.aeped.es/screens/play/5… @aepediatria #dermatology
2/5
@aepediatria El eccema coxsackium puede producir fiebre con pápulas, vesículas y costras confluyentes en región peribucal, cuello, tronco, antebrazos, pantorrillas y dorso de manos y pies.

Generalmente, una enfermedad autolimitada con buen pronóstico.
3/5

@ContinuumAEP #Pediatrics
Read 5 tweets
Jun 6
Multi-country #monkeypox #outbreak: situation update

780 laboratory confirmed cases of monkeypox have been reported to or identified by #WHO from 27 Member States across four WHO regions that are not endemic for monkeypox virus.
1/9

who.int/emergencies/di…
#Monkeypox outbreaks in endemic countries in the #African región, 2022.

1408 suspected and 44 confirmed cases including 66 deaths were reported from seven endemic countries
2/9
WHO #Risk assessment: MODERATE considering this is the first time that many #monkeypox cases and clusters are reported concurrently in non-endemic and endemic countries in widely disparate WHO geographical areas.
3/9
Read 9 tweets
Jun 6
La #OMS eleva a 780 los casos (0 muertes) de #ViruelaDelMono en 27 países (fuera de los endémicos donde se alcanzó 1.408 casos sospechosos y 66 muertes)
Más casos en:
1⃣207, Reino Unido
2⃣156, España
3⃣138, Portugal
4⃣58, Canadá
5⃣57, Alemana
1/3

rpp.pe/p/1409769
En lo que va de año, entre los países endémicos (1.408 casos sospechosos de #ViruelaDelMono y 66 muertes), la mayoría se detectó en la República Democrática del #Congo aunque también con más de una decena de contagios en Camerún, República Centroafricana y Nigeria.
2/3
Muchos pacientes de países no endémicos (no en Africa):
✔️erupciones cutáneas en zonas genitales y anales (sugiere el contacto sexual)
✔️detectados en consultas de salud sexual "involucran principalmente, pero no exclusivamente, a hombres que mantienen sexo con otros hombres"
3/3
Read 4 tweets
May 30
Niña de 5 años, araña entre las sábanas (1): fiebre de 2 días y placa eritematosa indurada en muslo con crecimiento centrífugo y una escara necrótica central (2)
¼

✏️M. Sendín-Martín y col. @HospitalUVRocio
DOI: 10.1016/j.anpedi.2020.12.005
#pediatria #Pediatrics
@HospitalUVRocio PICADURA DE LA ARAÑA RECLUSA PARDA

Las arañas del género Loxosceles o arañas reclusas o arañas violinistas debido a la morfología dorsal de su cefalotórax tienen una distribución mundial

La lesión se resolvió los días siguientes, sin dejar cicatriz.
2/4

#MedEd #dermatology
@HospitalUVRocio Las arañas reclusas parda causan lesiones necróticas a través de una enzima denominada esfingomielinasa D1. Los síntomas sistémicos incluyen fiebre o náuseas.

De forma infrecuente, signos graves como coagulación vascular diseminada o la rabdomiólisis
3/4
#IDtwitter #MedTwitter
Read 5 tweets

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