The pustular rash across the patient’s buttocks & back is likely secondary to CLM folliculitis—a rarer, but well-described skin manifestation of CLM 2/
These hookworms live in the intestines of domestic pets and shed their eggs via feces
Humans are infected by contact with contaminated soil or sand
The larvae migrate through the skin, leaving a characteristic “serpiginous” inflammatory cutaneous track 4/
Loeffler syndrome is usually caused by a hypersensitivity reaction during the migration of larval parasites through the lungs.
When associated with CLM, it is unclear whether the primary mechanism is direct invasion by Ancylostoma or a systemic immunological response
6/
The prognosis of Loeffler syndrome in the setting of CLM is excellent
Ivermectin:
- His rash improved after 48 hours,
- his cough had reduced by 1 week
- symptoms had fully resolved at 2 weeks,
- X-ray findings & eosinophil count returned to normal. 7/
51-YO🧔♂️alcoholic homeless living with dog in southern France: fever, confusión, a maculopapular rash on the trunk (A), hypotension, disorientation, an eschar on his right shoulder (B), & several tiny black spots
Platelet:⬇️
AST, ALT, GGT, LDH:⬆️ 1/
Careful examination: these spots were actually #ticks (a total of 22) attached on the skin; they were removed
During 25 h, he was examined by diferente doctors. Dermatologic examination was woefully incomplete, as often occurs when unhygienic, homeless, &/or drunken patients
2/
All ticks were identified as #Rhipicephalus sanguineus, the brown dog tick, including 1 female (A) and nymphs (B).
MEDITERRANEAN SPOTTED FEVER IN ITS MALIGNANT FORM 3/
Se sugiere que el enigma de la #hepatitis aguda grave de etiología desconocida en #niños lo explica la coinfección con #adenovirus y virus adenoasociado de tipo 2 (AAV2), y con menos frecuencia el virus del herpes 6 (HHV6) 1/ 👇 espanol.medscape.com/verarticulo/59…
Dos estudios independientes: Un estudio fue dirigido por la University of Glasgow, en Glasgow, y el otro por el Great Ormond Street Hospital de Londres, ambos en Reino Unido.
2/
Los investigadores del estudio de Glasgow usando secuenciación y PCR, confirmaron la presencia de virus adenoasociado de tipo 2 en el plasma de los 9 casos de hepatitis de inicio agudo y en el hígado de los 4 pacientes analizados.
3/
Mystery #hepatitis cases in #kids linked to unexpected viral suspect
Two preliminary studies finding #adeno-associated viruses in pediatric hepatitis cases suggest a child's genetic background and other virusesall act in concert 1/ 👇 science.org/content/articl…
Researchers found high adeno-associated virus 2 (AAV2) levels in the blood or liver cells in 24 of 25 children with unexplained hepatitis.
In a group of kids without this condition, almost none had AAV2, even those with #adenovirus.
2/
The young #hepatitis patients were also much likelier to have a #genetic variant that may make their immune systems overreact to viruses.
3/
#Monkeypox Virus Infection in Humans across 16 Countries, NEJM
Authors report 528 infections diagnosed in 16 countries.
75% were White.
41% had human immunodeficiency virus infection
The median age was 38 years. 1/ 👇
DOI: 10.1056/NEJMoa2207323
Transmission was suspected to have occurred through sexual activity in 95% of the persons with infection.
Overall, 98% of the persons with infection were gay or bisexual men. 2/
In this case series, 95% of the persons presented with a rash (with 64% having <10 lesions), 73% had anogenital lesions, and 41% had mucosal lesions (with 54 having a single genital lesion).
42-YO African American man, AIDS, CD4 57 cells/ mm3: 18-mth of progressively multiple papules coalescing into large exophytic nodules & plaques on face, scalp, & neck (A & B); & several lesions in in the groin, penis, & RUE
🔬:? 1/
Well-circumscribed intraepidermal lobules containing molluscum bodies (arrow)
These structures, which are composed of viral particles & cellular debris, are pathognomonic for this condition
Molluscum bodies enlarge and rise to the surface as cells age 3/