Discover and read the best of Twitter Threads about #Virology

Most recents (24)

A 31-YO♂️, #sexually active with 2♂️partners in the previous month: 8 days before redness of the R eye, an itchy perianal rash & rectal pain; scattered, tender, shallow ulcers & pustules on chest (A), abdomen (B), back (C) & perianal (D)
#proctology Image
PCR from the perianal vesicel:➕for nonvariola orthopoxvirus DNA.
Species-specific PCR: ➕for #mpox virus, clade II.

The patient reported a new rash with numerous ulcer on his chest, abdomen, and back

MPOX (formerly known as #monkeypox)

#MolBiol #virology
During the next 2 days, the patient took tecovirimat & reported redness & discomfort of the right eye and become painful

He had learned that mpox had been diagnosed in one of his #sexual partners from the previous month.


#ophthalmology #IDtwitter On examination of the right...
Read 9 tweets
3 años ♀️, padre con lesiones cutáneas similares: lesiones cutáneas polimorfas localizadas en los glúteos, con elementos papulares, vesiculares y pustulosos umbilicados

🖊️M Roguera y col. @hgermanstrias @aepediatria
DOI: 10.1016/j.anpedi.2022.09.006
#pediatria #infecciosas Lesiones cutáneas en glúteo izquierdo. Detalle de las lesi
@hgermanstrias @aepediatria Se confirmó en el padre la infección por virus de la viruela del mono (MPXV).

PCR de líquido vesicular de las lesiones:➕para MPXV.


#MolBiol #virology #virología
@hgermanstrias @aepediatria Se realizó aislamiento de contacto y secreciones respiratorias (aérea y gotas) en el domicilio hasta la curación completa de las lesiones cutáneas (a los 10 días de evolución).
No hubo complicaciones ni nuevas lesiones en el seguimiento.

#IDtwitter #microbiología
Read 12 tweets
1/ The impact of #Covid on $PVCT’s R&D, #DrugDiscovery, and clinical development of our #HalogenatedXanthene (#HX) medical science platform and #RoseBengalSodium (#RBS) investigational drug & drug formulation pipeline. A #THREAD.
2/ This $PVCT #thread will be an ongoing one for some time. Please check back to read it again (and again), and learn more about our medical scientific history and our lead molecule #RoseBengalSodium’s journey to becoming a multi-disease, broad-spectrum, therapeutic compound.
3/ #Covid has been a deeply painful experience, to say the least, for the U.S. and the world. It also marked a turning point in the advancement and expansion of our #HX medical science platform, as well as our lead molecule #RoseBengalSodium and the investigational drugs and drug……
Read 63 tweets
THREAD: #Virology: Unmasking a 100+ Year Old Lie

Everything You Think You Know About Disease Is Likely Wrong.

#vaccinegenocide #vaccines #vaccinedeath #PfizerLiedPeopleDied #thread…
We Need To Base Our Understanding of Reality Upon Reality, Not Manipulation.

Everything You Think You Know About Disease Is Likely Wrong....
In order to understand the world around us as the truth about it is emerging from a 100+ year slumber, it’s going to be important to challenge ideas that have absolutely zero basis in reality.

I will start off by saying that we have been duped - ALL OF US.
Read 266 tweets
A 38-YO♂️, #HIV➕: asthenia, fever, & generalized & confluent maculopapular rash predominantly on the back, cervical & inguinal lymphadenopathies, & stippled petechial hemorrhages in the soft palate (Forchheimer’s spots)
Subsequently, pustules appeared

#emergency #IDtwitter
Classic Mpox pustules appeared
✔️for measles & rubella➖
✔️for Mpox➕

HUMAN Mpox, although confluent maculopapular rash & Forchheimer’s spots have been reported as classic signs of rubella or measles infections

#microbiology #MedTwitter
Forchheimer spots, a type of enanthem:
📌sometimes precede the skin rash of rubella.
📌tiny red spots on the soft palate in rubella, measles and scarlet fever.

#dermatology #internalmedicine #primarycare
Read 5 tweets
A 27-YO ♀️, fever and PCR + for #SARSCoV2: One week later, she developed migratory, pruritic urticarial erythematous plaques (wheals) on her face, limbs, trunk, palms & soles, and angioedema of her lips.

#dermtwitter #IDtwitter #MedTwitter
Treated with cetirizine, 12 weeks later, she was still having episodes of urticaria
The most likely diagnosis was CHRONIC SPONTANEOUS URTICARIA TRIGGERED BY SARS-CoV-2, but other considerations were urticarial vasculitis and chronic inducible urticaria.

#dermatology #Doctor
Urticaria is commonly triggered by viral & bacterial infections, including herpes simplex virus, cytomegalovirus, Epstein–Barr virus, HIV & mycoplasma.

It commonly precedes or occurs concurrently with COVID-19, but can rarely occur after symptoms have resolved.

Read 4 tweets
A 27-YO ♂️ with #HIV & #syphilis, condomless receptive & insertive vaginal, anal, & oral intercourse with male & female partners: a diffuse, erythematous, macular rash (involved the palms) & umbilicated, pustular lesions on face, arms (A), legs, trunk (B, flank) & neck (C)
PCR swabbed lesions:➕for #monkeypox

MONKEYPOX in a sexually-active man with HIV and SYPHILIS

He was started on antiretroviral therapy for his recent diagnosis of HIV, & administered IM benzathine penicillin G for syphilis.
#IDtwitter #dermatology
As direct contact is the primary mode of transmission, sexual intimacy has been identified as a risk factor for #Mpox, and a high proportion of the current multinational outbreak has been in men who have sex with men.

#MedTwitter #Doctor
Read 7 tweets
A 39-YO ♂️, same-sex relationships involving condomless anal sex: 38°C, cervical lymphadenopathy, mucosal ulceration on his tongue and a maculopapular rash on his face, neck and anterior chest.

#Doctor #emergency #dermatology
RPR: ➖
Immunoassay:➕for HIV antibodies
HIV-1 blood viral load: 4.79 million copies/mL
Blood CD4 T-cell count of 0.1 × 109/L.


Started antiretroviral treatment with bictegravir–emtricitabine–tenofovir alafenamide.

#IDtwitter #microbiology
Features of acute HIV infection occur 2–4 weeks after exposure.
Common presentation includes fever, arthralgia and lymphadenopathy, which may mimic acute mononucleosis.

Seroconversion usually occurs 3–8 weeks after initial infection.

#virology #MedTwitter
Read 5 tweets
A 49-YO♀️: fever, myalgia, headache, blanching papular rash on her trunk & limbs, & conjunctivitis (1)
Neutropenia & mild hepatitis
The patient's husband accompanied the patient to the Cook Islands: a highly similar rash (2)
#IDtwitter #microbiology
Arboviral infection was suspected.
Pan-flavivirus PCR: ➕
PCR was sequenced, & a BLAST search: ➕ for Zika virus.


The wife (and her husband): recovery over 5 days with no specific treatment.
2/ 6…
#virology #MedTwitter #MolBiol
Zika virus, endemic to Southeast Asia & Africa, is transmitted by Aedes species mosquitoes.

Clinical manifestations (fever, maculopapular rash, myalgias, and headache) are similar to other arboviral infections, such as dengue and chikungunya,

#dermatology #Doctor
Read 6 tweets
82 años♂️, DM, dislipemia, y enfermedad arterial periférica: dolor torácico anginoso con semiología de insuficiencia cardiaca.
ECG:⬆️segmento ST en V2-V3 y DI-AVL.
Coronariografía: arterias coronarias sin lesiones

#cardiologia #urgencias #MedicinaInterna
Ventriculografía: fracción de eyección del ventrículo izquierdo muy reducida a expensas de acinesia apical extensa.


DOI: 10.1016/j.recesp.2020.06.022
#IDtwitter #Cardiology
El ecocardiograma confirmó los hallazgos de la ventriculografía

Rx de tórax: signos de insuficiencia cardiaca leve, sin evidencia de neumonía.

Buena evolución, con mejoría del cuadro de insuficiencia cardiaca.

#MedTwitter #Doctor
Read 7 tweets
An 81-YO👵, type 2 DM: malaise, fever & anorexia, with oral pain & odynophagia, yellowish-white, pseudomembranous lesions on the tongue (A)

#endoscopy showed multiple shallow ulcers with a white coating (B)
#emergency #gastroenterology #MedEd
Glossal & esophageal🔬: multinucleated cells with moulded, ground-glass nuclei

PCR & immunohistochemical staining of the specimens: ➕ for herpes simplex virus type 1 (HSV-1)


#GIPath #IDtwitter #microbiology
Her hemoglobin A1c was 7.2%.

Doctors treated her with a 7-day course of acyclovir, intravenously because of her odynophagia, and the oral and esophageal lesions completely resolved.

#MedStudentTwitter #MedicalStudents
Read 6 tweets
🦠Sars-Cov-2 escaped detection in these
2⚠️immunocompromised patients
...good thing these inquistive teams dug "deeper."… #bioinformatics #openscience #itrtg #COVID19 #iot #scicomm #immunology #virology
"2 cases occult SarsCov2 in immunocompromised hosts: Dx originally not suspected due to repeat negative SARS-CoV-2 from NP specimens
isolation of viable SARS-CoV-2 virus + nucleocapsid + spike-protein antigen in lung tissue on immunohistochemistry 3-months from primary infection"
"suggests ongoing 🦠viral persistence and replication as a driver of the lung parenchymal changes,
which resolved after antiviral treatment."
Both patients survived:
discharged on days 80 and 100 respectively.
Read 4 tweets
42-YO African American man, AIDS, CD4 57 cells/ mm3: 18-mth of progressively multiple papules coalescing into large exophytic nodules & plaques on face, scalp, & neck (A & B); & several lesions in in the groin, penis, & RUE
#dermatology #idtwitter ImageImage

Molluscum contagiosum is a benign skin tumor caused by molluscum contagiosum virus.

Lesions >1 cm diameter are known as giant molluscum

#Virology #MedEd #MedTwitter
Well-circumscribed intraepidermal lobules containing molluscum bodies (arrow)
These structures, which are composed of viral particles & cellular debris, are pathognomonic for this condition
Molluscum bodies enlarge and rise to the surface as cells age

#Doctor #dermatologia Image
Read 8 tweets
🦠This is dreaded
"Marburg Virus"🔬 (Video: PLOS)
- case-fatality-rate up to 9⃣0⃣%
🩸hemorrhaging from all orifices leads to death
*⃣ 2 patients in Ghana have just tested positive… #scicomm #openscience #medtwitter #snrtg #virology
Marburg Virus is classified as a hemorrhagic fever virus. It is closely related to Ebola Virus.
Some scary viruses out there beyond Sars-Cov-2.
Ghana reports first-ever suspected cases of Marburg virus disease… #openscience #scicomm
Read 4 tweets
New 🧬genetic loci linked to #COVID19 🦠susceptibility
♂️ ♀️ with gender specificity
- Results from a huge 🇪🇸 Spanish GWAS study… #bioinformatics #openscience #scicomm #immunology #virology #snrtg #genomics Image
🦠🧬'...variants in 3p21.31 and 21q22.11 loci only among males ♂️; and variants in 9q21.32 near TLE1 only among females ♀️'
Evidence continues to accumulate that:
at least *⃣ for some *⃣ , susceptibility to severe and fatal 🦠COVID may lie in the genes🧬.
Read 4 tweets
Daily Bookmarks to GAVNet 12/31/2021…
How to Create a Health Care Crisis ⋆ Brownstone Institute…

#PublicHealth, #HealthCareSystem, #PandemicResponse
The Risk of Vaccinated COVID Transmission Is Not Low - Scientific American…

#COVID19, #transmissibility, #vaccinations, #InfectionRisk
Read 15 tweets
Coincidence of a series of coincidences ! This thread is for those who love 💘 #coincidences. A 🧵 ... 1/n
It is just a coincidence that the World Economic Forum (#WEF) and Bill Gates et al reviewed a meeting in 2019 and predicted about a possible future viral pandemic, just before the #COVID #pandemic. It must be another plain coincidence that a viral pandemic began exactly 2/n
.. in the place where there is a level-4 #virology laboratory (#Wuhan). It was a coincidence that, whole world followed China's #lockdown policy with ZERO #scientific and #economic basis. 3/n
Read 8 tweets
First Dose!
I'm very excited to be joining #GenXZeneca . Even though it took a bit to get an appointment, the process itself was super fast and painless.

This week also marks the conclusion of the undergraduate immunology course I run. As getting vaccinated is basically a live-demo summary of the entire course, I thought I'd celebrate by live-tweeting my immune response to the vaccine.
#Nerdy , but fun!
(I'm not sure how many of my students would agree about the "fun" part, but I doubt any are on twitter anyway and so they get out of this impromptu lab component).
Let the #LiveTweet begin!
Read 133 tweets
A #virology evolutionary hypothesis on this one - it is *likely* less virulent, more transmissible than B.1.1.7/B.1.617

Less mutations head to head in multiple ORFs, yet seemingly rapid increase in prevalence in face of competing B.1.617.

Thoughts? @thattai @dylanhmorris
Mutations in B.1.1.7 and B.1.617, both well established, lineages would have been fixed for some benefit. For nature to choose *not* to fix them in B.1.618 implies some benefit of losing them. Of course, protein allostery incredibly hard to predict a priori, but Occam's razor..
..along with the increasing prevalence of B.1.618 in West Bengal while B.1.617 also expands would suggest increased transmissibility and lower virulence. Immune escape propensity is a different issue altogether of course.

Read 6 tweets
@KPcolorado knew a vaccine was coming for at least 9 months, but didn't use the time to construct systems to ensure efficient and timely vaccinations of seniors.
Seniors who use #Medicare ... so
essentially tax dollars were wasted. We will need investigations and transparency so future public health disasters are better handled. @jaredpolis put senior lives in the hands of providers that lack the capacity
and the capability for an essential task. This despite reams of research that says provider communication is key to successful health outcomes.
We knew our health system was piss-poor at managing #chronicdisease- CVD, metabolic syndrome, obesity
Read 11 tweets
Vaccine received! I almost cried. As I was receiving the vaccine, I felt profound hope, joy and relief.
#shot #vaccine #covidvacccine #pfizer #mrna #spikeprotein #frontlineworkers #healthcareworkers #doctor #navajo #immunology #microbiology #virology #publichealth
I have been working on the front lines of COVID-19 on the Navajo Nation since March. Once, we were #1 in the WORLD per capita.
#vaccine #covidvacccine #pfizer #spikeprotein #frontlineworkers #healthcareworkers #doctor #navajo #immunology #microbiology #virology #publichealth
Today marks a new path towards having a world without COVID. Bless the tireless researchers and brave vaccine trail participates who made this possible.
#vaccine #covidvacccine #pfizer #frontlineworkers #healthcareworkers #doctor #navajo #immunology #microbiology #virology
Read 3 tweets
Following up on yesterdays tweet: how to „count“ viruses? The technique is called „plaque assay“ and I’ll share my teaching slide on it below. The gooey medium keeps offspring viruses from swimming around➔ only infect adjacent cells, creating circular holes in the cell layer. 1/ Image
2/ And once you have counted (and documented!) the plaques (i.e. „holes“) from all your countless plates, have fun:
3/ Acknowledgments for the basis of the slide go to Barbara Müller, and for sharing the photo of the SARS-CoV2 plaque assay to Ralf #Bartenschlager and his SARS gang (mainly @mirkocortese), all @CiidHeidelberg @uniklinik_hd @UniHeidelberg
Read 4 tweets

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