Raj Rajnarayanan Profile picture
Oct 8 12 tweets 15 min read
Tracking #SARSCoV2 #Convergent #Lineages ( aka #VariantSoup) over time - Globally | #30DayTrends

BQ.1 (#Typhon)/BQ.1.1(#Cerberus) are currently at the top & BA.2.75.2* (#Chiron) is not far behind!

Tracker: public.tableau.com/app/profile/ra…

Updated 10/7/2022 Image
Granular details - #VariantSoup with Convergent Mutations #30DayTrends

BQ.1/BQ.1.1 and BA.2.75.2 are heading the charts!

2/n Image
Tracked #Convergent #lineages are predicted to be immune evasive and bind to host ACE2 receptor better than Omicron.BA2

XBB is most immune evasive
Most BA.2.75* binds better to ACE2 receptors

Closely watched lineages - XBB, BM.1.1.1, CA.1, BQ.1.1, BN.1

3/n Image
#Singapore is a #XBB* (aka #Gryphon) hotspot (#30DayTrends)

4/n Image
#UnitedKingdom, #USA, #Denmark, #France, and #Belgium are BQ.1.1* hotspots (#30DayTrends)

5/n Image
#USA, #Singapore, #Denmark, #Austria, #Australia, #Canada are emerging BA.2.3.20* hotspots (#30DayTrends)

6/n Image
#Singapore is an emerging BM.1.1.1 (#Mimas) hotspot (#30DayTrends)

9/n Image
List of "unofficial" variant nicknames for easy social media communication

H/T @TRyanGregory
Why are we watching these lineages?



11/n
Live tracking of convergent lineages with the
@GenSpectrum #Collection54 by @CorneliusRoemer

cov-spectrum.org/collections/54

12/n Image

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More from @RajlabN

Oct 10
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

20.0% BA.5.2.1
12.7% BA.5.2
12.7% BA.4.6
8.6% BA.5.1
4.8% BQ.1👀
3.6% BF.7
2.6% BQ.1.1👀
2.1% BA.5.6
2.1% BF.10
1.8% BA.5

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/09/22
1/n Image
Charts represent #15DayTrends

~50% of sequences are from #NewYorkCity!

919 sequences out of 1825 total sequences uploaded in @GISAID from #USA with sample collection dates in the last 15 days!

2/n
44 of the 1825 sequences are from opt-in airport screening

Mostly Asymptomatic

5 BQ.1.1 (2-NJ, 2-NY, 1-CA)
2 XBB (NJ, CA airport)
1 BA.2.3.20 (GA)
1 BN.1 (CA)
1 BY.1 (NJ)
1 BM.1.1.1 (NJ)
1 BA.2.75.2 (NJ)

Time to bring back Universal Masking in the Transportation Sector!

3/n
Read 13 tweets
Oct 9
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

23.3% BA.5.2.1
14.7% BA.5.2
13.0% BA.4.6
8.9% BA.5.1
2.8% BF.10
2.4% BA.5.5
2.4% BA.5.6
2.3% BF.7
2.1% BA.5.2.9
1.6% BA.5

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/08/22
1/n
Top circulating lineages (#15DayTrends)

78.6% BA.5*
13.0% BA.4.6*
2.3% BF.7*
1.7% BA.4*
1.3% BA.2.75*
1.3% BQ.1*
1.1% BQ.1.1*
0.2% XBB*
0.1% BA.2.3.30*

2/n Image
.@CDCgov updated variant proportions estimates on 10/7/2022



3/n
Read 11 tweets
Oct 8
#SARSCoV2 #Variants are collecting identical sets of concerning mutations (aka #Convergent #Evolution)

Latest threat is from the recombinant lineage #XBB (BJ.1/BM.1.1.1), the most immune-evasive #COVID strain seen yet

H/T @ErinMPrater @FortuneMagazine
XBB (aka #Gryphon) is the most immune evasive lineage.

BA.2.75* sub-lineages bind better to host ACE2 receptor.

XBB could pick up addition mutations to optimize its ACE receptor binding!

Read 7 tweets
Oct 7
CDC #NOWCAST #VariantProportions Predictions
- #USA (updated on 10/07/22)

79.2% BA.5*
13.6% BA.4.6* ⬆️
4.6% BF.7*
1.8% BA.2.75* 👀
0.8% BA.4

Get #Boosted and #MaskUp

Source: covid.cdc.gov/covid-data-tra…

@CDCgov Image
Consistent with #COVID19 #VariantDashboard - #15DayTrends

Top circulating lineages (#15DayTrends)

80% BA.5*
12% BA.4.6*
2% BF.7*
1.5% BA.4*
1.3% BA.2.75*
1.1% BQ.1*
0.9% BQ.1.1*
0.3% BA.2.3.30*
0.1% XBB*

CDC Nowcast Estimates – Regions 1-4 & 7 are BA.4.6* Hotspots Image
Read 4 tweets
Oct 7
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

18.5% BA.5.2.1
15.4% BA.5.2
12.0% BA.4.6
10.3% BA.5.1
3.6% BF.10
3.2% BA.5.5
2.6% BA.5.2.9
2.6% BA.5.6
2.0% BA.5
2.0% BF.7

Tracker: tinyurl.com/mryj4uu7

#OmicronUpdates 10/06/22
1/n
Top circulating lineages (#15DayTrends)

80% BA.5*
12% BA.4.6*
2% BF.7*
1.5% BA.4*
1.3% BA.2.75*
1.1% BQ.1*
0.9% BQ.1.1*
0.3% BA.2.3.30*
0.1% XBB*

2/n
.@CDCgov updated variant proportions estimates on 9/30/2022



3/n
Read 14 tweets
Oct 7
Tracking #SARSCoV2 #Convergent #Lineages ( aka #VariantSoup) over time - Globally | #30DayTrends

BQ.1 (#Typhon)/BQ.1.1(#Cerberus) are currently at the top & BA.2.75.2* (#Chiron) is not far behind!

Tracker: public.tableau.com/app/profile/ra…

Updated 10/6/2022
Granular details - #VariantSoup with Convergent Mutations #30DayTrends

BQ.1/BQ.1.1 and BA.2.75.2 are heading the charts!

2/n
Tracked #Convergent #lineages are predicted to be immune evasive and bind to host ACE2 receptor better than Omicron.BA2

XBB is most immune evasive
Most BA.2.75* binds better to ACE2 receptors

Closely watched lineages - XBB, CA.1, BQ.1.1, BN.1, BR.3

3/n
Read 12 tweets

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