Intermittent #fasting (IF) results in remission (A1C<6.5%) of type 2 #diabetes (T2D)

1. According to a recent trial on IF in people with T2D, 47% achieved remission at 3 months and 44% were still in remission at one year.
#MedTwitter
doi.org/10.1210/clinem…
2. Group following IF had 5.9 kg #weightloss at 3 months, as compared to only 0.3 kg weight loss in the control group.
3. This study presented a novel type of intermittent fasting. The intervention consisted of 6 cycles (3 months) of 5 fasting days followed by 10 ad libitum days, and then 3 months of follow-up (with no fasting days).
4. 65% of the patients in the intervention (IF) group who achieved diabetes remission had had diabetes for more than 6 years, which suggests the possibility of remission for patients with longer duration of diabetes.
5. Take home message
Intermittent fasting can be a valuable strategy in achieving remission of type 2 diabetes mellitus.
IF results in significant weight loss, which could contribute to remission of T2D.
Patients with long-standing diabetes (6 years) too can hope for remission.
840 kcal/day (46% carbohydrates, 46% fat, 8% protein): breakfast of a fruit and vegetable gruel, lunch of a solid beverage plus a nutritional rice composite, and dinner of a solid beverage and a meal replacement biscuit, which participants reconstituted by mixing with water.
Above diet was for fasting days.
On non-fasting days, patients chose foods ad libitum as per Chinese guidelines: 50% to 65% of total energy intake from carbohydrates, 15% to 20% from protein, and 20% to 30% from fat, and ≥ 5 g fiber per serving.

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More from @hyderabaddoctor

Dec 16
The less we eat, the longer we live

1. This seems to be true.
A recent extensive review of studies done in geographies with maximum 100+ aged people showed that most of them practiced some form of calories restriction (CR) right from childhood.
#fasting #Longevity #MedTwitter
2. Calorie restriction (CR) is defined as consuming fewer (10-30% lower) calories as compared to usual.
This can be achieved by either intermittent fasting, or time-restricted feeding or substantially reducing carbohydrate intake.
#nutrition #HealthyEating
3. In ageing, #Insulin increases and insulin sensitivity decreases, which increase the risk of #diabetes, #obesity and #cardiovascular diseases. CR reverses these- reduces insulin levels and increases insulin sensitivity. #Glucose levels also reduce with CR.
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2. A 50-year old man consulted me 6 months ago for a second opinion. He had complaints of difficulty in swallowing, slurred speech, weakness and wasting of muscles of arms and legs, which had progressed over previous 9 months.
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1. 42-year old woman consulted me last month with complaints of constant urge to move her right leg for past 12 years. Symptoms occurred mostly in evenings and nights.
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2. She would develop crawling sensation and discomfort in right leg while sitting for long or lying down, which would go away only after she jerked or vigorously shook her leg.
She remained reasonably well during the day.
3. These symptoms occurred on daily basis causing sleep disturbance (she could #sleep only 5 hours at night).
She felt tired during day and found it hard to concentrate.
She was unable to sit for long while travelling or during meetings during daytime.
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Dec 13
Sharing a few tips that could enrich doctor-patient relationship
1. I saw my first patient in 1994. During past three decades, I have learnt a lot from my patients while interacting with them. These tips could help younger doctors who have recently started this amazing journey.
2.Listen to patients: The clues to diagnosis often lie in patient’s history. Moreover, if patients are properly heard, they feel satisfied. Occasional chronic patients may have thick files; it is still worthwhile letting them narrate the story, especially if it is the first visit
3. If patient requests for a test, accept it, even if the chance of it being abnormal is low. Patients understand their body well, and you will be surprised to find an abnormality in the test they wanted and you felt it was not needed.
#MedTwitter #doctors
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Dec 12
When an old woman started speaking in a "foreign" accent all of a sudden
1. About a year back, a 70-year old woman was brought by her son to my OPD. As per him, she had started to speak Telugu in an "American" accent, since waking up that morning.
#MedTwitter #NeuroTwitter
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#MedTwitter #gynecologist
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3. Of the total association of endometriosis
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