Thread by @hyderabaddoctor

Intermittent #fasting (IF) results in remission (A1C<6.5%) of type 2 #diabetes (T2D)

1. According to a recent trial on IF in people with T2D, 47% achieved remission at 3 months and 44% were still in remission at one year.
#MedTwitter
doi.org/10.1210/clinem…

2. Group following IF had 5.9 kg #weightloss at 3 months, as compared to only 0.3 kg weight loss in the control group.

3. This study presented a novel type of intermittent fasting. The intervention consisted of 6 cycles (3 months) of 5 fasting days followed by 10 ad libitum days, and then 3 months of follow-up (with no fasting days).

4. 65% of the patients in the intervention (IF) group who achieved diabetes remission had had diabetes for more than 6 years, which suggests the possibility of remission for patients with longer duration of diabetes.

5. Take home message
Intermittent fasting can be a valuable strategy in achieving remission of type 2 diabetes mellitus.
IF results in significant weight loss, which could contribute to remission of T2D.
Patients with long-standing diabetes (6 years) too can hope for remission.

840 kcal/day (46% carbohydrates, 46% fat, 8% protein): breakfast of a fruit and vegetable gruel, lunch of a solid beverage plus a nutritional rice composite, and dinner of a solid beverage and a meal replacement biscuit, which participants reconstituted by mixing with water.

Above diet was for fasting days.
On non-fasting days, patients chose foods ad libitum as per Chinese guidelines: 50% to 65% of total energy intake from carbohydrates, 15% to 20% from protein, and 20% to 30% from fat, and ≥ 5 g fiber per serving.