Thread by @ProvectusBio

1/ A THREAD on what $PVCT achieved in 2022. #event #discovery #milestone #milepost. #rosebengal #rosebengalsodium.

2/ $PVCT 2023 Stockholder Letter (released January 9th).

https://twitter.com/ProvectusBio/status/1612438924206702594

. #rosebengal #rosebengalsodium.

3/ $PVCT #clinical and #research collaborators made 6 presentations at 5 medical conferences about PV-10 for different cancers. #ENETS22 #AACR22 #ASCO22 #ISOO2022 #melanomabridge. #presentations. #rosebengal #rosebengalsodium.

4a/ $PVCT. Neuroendocrine tumors (NET) metastatic to the liver (mNET) refractory to somatostatin analogs and peptide receptor radionuclide therapy (NCT02693067) at the European Neuroendocrine Tumor Society annual conference. #ENETS22 #ENETS2022. #rosebengal #rosebengalsodium.

4b/ $PVCT. Phase 1 study of Intralesional (IL) rose bengal (PV-10), an investigational autolytic immunotherapy (oral). provectusbio.com/media/presenta…. #rosebengal #rosebengalsodium #PV-10 #clinical.

4c/ $PVCT #clinical collaborator Prof Tim Price MBBS DHthSc (Med) FRACP. gicancer.org.au/director/prof-…. #PV-10.

5a/ $PVCT. High-risk and refractory adult solid tumor cancers (preclinical) at the annual meeting of the American Association for Cancer Research. #AACR22 #AACR2022. #rosebengal #rosebengalsodium.

5b/ $PVCT. Identification and In Vivo Validation of Unique Anti-Oncogenic Properties and Mechanisms Involving Protein Kinase Signalling and Autophagy Mediated by the Investigational New Agent PV-10 (poster). provectusbio.com/media/docs/pub…. #rosebengal #rosebengalsodium.

5c/ $PVCT #research collaborator Prof Aru Narendran MD PhD. charbonneau.ucalgary.ca/our-members/ou…. #rosebengal #rosebengalsodium #PV-10.

6a/ $PVCT. Uveal melanoma (UM) metastatic to the liver (mUM) (NCT00986661) at the American Society of Clinical Oncology annual meeting. #ASCO22 # ASCO2022. #rosebengal #rosebengalsodium #PV-10.

6b/ $PVCT. Metabolic complete responses (mCR) in metastatic uveal melanoma (mUM) patients treated with image-guided injection (IGI) of PV-10” (poster). provectusbio.com/media/docs/pub…. #rosebengal #rosebengalsodium #PV-10 #clinical. @DrSapnaPatel.

6c/ $PVCT #clinical collaborator Dr. Sapna Patel MD. @DrSapnaPatel. faculty.mdanderson.org/profiles/sapna…. #PV-10.

7a/ $PVCT. mUM (NCT00986661) at the 20th Congress of the International Society of Ocular Oncology (ISOO). #ISOO2022. #rosebengal #rosebengalsodium #PV-10.

7b/ $PVCT. #ISOO2022 Presentation 1. A phase 1 study of percutaneous autolytic rose bengal disodium for metastatic uveal melanoma patients with hepatic metastases (oral). provectusbio.com/media/docs/pub…. #rosebengal #rosebengalsodium #PV-10 #clinical. @DrSapnaPatel.

7c/ $PVCT. #ISOO2022 Presentation 2. Metabolic complete responses (mCR) in metastatic uveal melanoma (mUM) patients treated with image-guided injection of PV-10 (oral). provectusbio.com/media/docs/pub… . #clinical #rosebengal #rosebengalsodium #PV-10. @DrSapnaPatel.

8a/ $PVCT. CB-naïve Stage III cutaneous melanoma (NCT01223415) at Melanoma Bridge. #rosebengal #rosebengalsodium #PV-10. #melanomabridge.

8b/ $PVCT. Response for combination of PV-10 autolytic immunotherapy and immune checkpoint blockade in stage III cutaneous melanoma (poster) provectusbio.com/media/docs/Mel…. #clinical #rosebengal #rosebengalsodium #PV-10.

8c/ $PVCT. Response for combination of PV-10 autolytic immunotherapy and immune checkpoint blockade in stage III cutaneous melanoma (oral video communication). provectusbio.com/media/docs/vid…. #clinical #rosebengal #rosebengalsodium #PV-10.

9a/ $PVCT. Journal publication of preclinical #research on pharmaceutical-grade #rosebengalsodium against Gram-positive bacteria. @Molecules_MDPI. #rosebengal.

9b/ $PVCT. Antibacterial Activity of Pharmaceutical-Grade Rose Bengal: An Application of a Synthetic Dye in Antibacterial Therapies (journal article). mdpi.com/1420-3049/27/1…. #research. #rosebengal #rosebengalsodium.

10/ $PVCT received 2 #patent awards from the #USPTO. @uspto. #IntellectualProperty #patentaward. #hematology #dermatology.

11. $PVCT. Composition and Methods for Treating Hematologic Cancers (11,419,844) patentimages.storage.googleapis.com/d4/cb/34/0c6fa…, which expires in December 2040. #USPTO #IntellectualProperty #patentaward #patent. #rosebengal #rosebengalsodium. #hematology.

12/ $PVCT. Combination of Local and Systemic Therapies for Enhanced Treatment of Dermatologic Conditions (11,426,379) patentimages.storage.googleapis.com/73/9f/11/862db…, which expires in November 2038. #USPTO #IntellectualProperty #patentaward #patent. #rosebengal #rosebengalsodium. #dermatology.

13/ $PVCT had 3 patent applications published on the #USPTO website. @uspto. #IntellectualProperty #PatentApplication #patent. #oncology #vaccines #dermatology.

14/ Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer (17/382,943) patentimages.storage.googleapis.com/5f/7b/59/21cd4…. #IntellectualProperty #PatentApplication #patent. #rosebengal #rosebengalsodium. #oncology.

15/ Halogenated Xanthenes as Immune Adjuvants (17/488,430) patentimages.storage.googleapis.com/68/98/e1/8c678…. #IntellectualProperty #PatentApplication #patent. #rosebengal #rosebengalsodium. #vaccines.

16/ Combination of Local and Systemic Therapies for Enhanced Treatment of Dermatologic Conditions (17/466,600) patentimages.storage.googleapis.com/d8/be/be/07153…. #IntellectualProperty #PatentApplication #patent. #rosebengal #rosebengalsodium. #dermatology.

17/ $PVCT expanded 3 existing sponsored research collaborations. #research. #rosebengal #rosebengalsodium.

18a/ $PVCT. The Rockefeller University for #dermatology. @RockefellerUniv #RockefellerScience. #research. #rosebengal #rosebengalsodium.

18b. $PVCT #research collaborator James G. Krueger, MD, PhD. rockefeller.edu/our-scientists…. @RockefellerUniv #RockefellerScience. #research. #rosebengal #rosebengalsodium.

19a/ $PVCT. The University of Tennessee Health Science Center for #InfectiousDiseases. @uthsc. #research. #rosebengal #rosebengalsodium.

19b/ $PVCT. $PVCT #research collaborator Michio Kurosu, PhD. uthsc.edu/faculty/profil…. mkurosu2.wixsite.com/kurosulab. @uthsc. #research. #rosebengal #rosebengalsodium.

20a/ $PVCT. The University of Calgary for #hematology. @UCalgary #UCalgary @UCalgaryMed #UCalgaryMed #ResearchMatters. #research. #rosebengal #rosebengalsodium.

20b. $PVCT #research collaborator Prof Aru Narendran MD PhD. charbonneau.ucalgary.ca/our-members/ou…. @UCalgary #UCalgary @UCalgaryMed #UCalgaryMed #ResearchMatters. #research. #rosebengal #rosebengalsodium.

21/ $PVCT initiated 4 new sponsored research collaborations. #research. #rosebengal #rosebengalsodium.

22/ $PVCT. The University of Tennessee (the College of Veterinary Medicine) for #AnimalHealth. @utcvm #research. #rosebengal #rosebengalsodium. #veterinarymedicine #veterinary.

23/ $PVCT. The University of Miami (the Ophthalmic Biophysics Center of Bascom Palmer Eye Institute) for #ophthalmology. @univmiami @BascomPalmerEye @UMiamiHealth #OBC. #research. #rosebengal #rosebengalsodium.

24a/ $PVCT. The University of Texas Medical Branch for #WoundHealing. @utmbhealth. #research. #rosebengal #rosebengalsodium.

24b/ $PVCT #TranslationalResearch collaborator Amina El Ayadi, PhD. @utmbhealth. scopus.com/authid/detail.….

25a/ $PVCT. The University of Nevada, Las Vegas for tissue regeneration and repair. @unlv @UNLVresearch. #research. #rosebengal #rosebengalsodium.

25b/ $PVCT #research collaborator Kelly Tseng, PhD. tseng.faculty.unlv.edu. @unlv @UNLVresearch. #research. #rosebengal #rosebengalsodium.

25c/ Tseng publication: From Cell Death to Regeneration: Rebuilding After Injury. frontiersin.org/articles/10.33…. @unlv @UNLVresearch. #research.

26/ $PVCT discovered that PV-10 may be an immune adjuvant in vaccines for cancer and viruses to improve immune response upon vaccination. @UCalgary #UCalgary @UCalgaryMed #UCalgaryMed #ResearchMatters. #research. #rosebengal #rosebengalsodium. patentimages.storage.googleapis.com/68/98/e1/8c678….

27/ $PVCT synthesized a second #HaolgenatedXanthene #molecule: 4,5,6,7-tetrabromo-3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodo-3H-spiro[isobenz- ofuran-1,9′-xanthen]-3-one. #chemistry #DrugDevelopment.

28/ $PVCT added Aru Narendran, MD, PhD to our Scientific Advisory Board provectusbio.com/scientific-adv…. @UCalgary #UCalgary @UCalgaryMed #UCalgaryMed #ResearchMatters. #research. #rosebengal #rosebengalsodium.

29/ $PVCT entered into an option agreement with @univmiami for an exclusive worldwide license of #IP for the use of a photodynamic antimicrobial therapy medical device in combination with our pharmaceutical-grade #rosebengalsodium API for the treatment of eye infections.

30/ $PVCT received the nonproprietary name of #rosebengalsodium for our pharmaceutical-grade API from @WHO Expert Advisory Panel on the International Pharmacopoeia and Pharmaceutical Preparations, and reached the status of recommended International Nonproprietary Names.

31a/ $PVCT completed chemical analytical work to rigorously and methodically compare and contrast lots of commercial-grade rose bengal from different specialty chemical suppliers with our pharmaceutical-grade #rosebengalsodium API. #DrugManufacturing. #rosebengal.

31b/ $PVCT. Preliminary results indicated that all 3 commercial-grade rose bengal lots had drastically different rose bengal purity from that represented on their certificates of analysis. 1 lot also contained gross contaminants not represented on its certificate. THREAD END.

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