Share this page!

Enter Twitter Thread URL to Unroll

Needs to be the full URL like: https://twitter.com/threadreaderapp/status/1644127596119195649

How to get URL link on Twitter App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Dr Sam Soete | Health Alchemist Profile picture
@sam_soete
May 29 • 6 tweets • 2 min read Twitter logo Read on Twitter
Master Thread on Statins: The Four Horsemen

1) How statins nuke your mitochondria

2) How statins cause T2DM

3) How statins cause CVD

4) How statins cause cardiomyopathy

#statins #bigpharma Image
I hope you enjoyed these deep dives into the MOA of statins.

If you learned something:

1) Retweet the first tweet

2) Follow me for more deep dives into health topics

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Dr Sam Soete | Health Alchemist

Dr Sam Soete | Health Alchemist Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @sam_soete

Dr Sam Soete | Health Alchemist Profile picture
May 30
Mitochondria: An Epic Origin Story

What are they? Where do they come from? And why are they here?

This 🧵unravels the mystery behind the origins of the most important and enigmatic organelle in our body.

#mitochondria #metabolism #science #biology Image
In the depths of time, when the universe was but a tender babe, an epoch unfathomable, there existed naught but primordial cells.

1.5 billion years ago, a singular ancient invasion by a eubacteria of an archea host occurred. Image
This invasion or engulfing, depending on who or what we give the moral high-ground, may have been the quintessential step in the most important evolutionary leap since the origin of life itself:

The transition from a primitive cell to a complex higher organism (eukaryote). Image
Read 45 tweets
Dr Sam Soete | Health Alchemist Profile picture
May 27
𝗦𝘁𝗮𝘁𝗶𝗻𝘀 destroy your skeletal muscle, why would they be any good for your 𝗵𝗲𝗮𝗿𝘁?

This 🧵 dives deep into mechanisms underlying statin induced cardiomyopathy.

#statins #cardiomyopathy #CHF #heartfailure #health #bigpharma Image
Over 64 million people suffer from heart failure worldwide.

To what extent is statin therapy contributing to the epidemic of congestive heart failure (CHF) worldwide?

Statin cardiomyopathy is a complication that can occur in 1-3% of people. Image
M𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮 are once again the linchpin linking statins to CHF.
Read 25 tweets
Dr Sam Soete | Health Alchemist Profile picture
May 26
The Art of War:

According to an old story, a lord of ancient China once asked his physician, a member of a family of healers, which of them was the most skilled in the art.
The physician, whose reputation was such that his name became synonymous with medical science in China, replied, “My eldest brother sees the spirit of sickness and removes it before it takes shape, so his name does not get out of the house.
“My elder brother cures sickness when it is still extremely minute, so his name does not get out of the neighbourhood. “As for me, I puncture veins, prescribe potions, and massage skin, so from time to time my name gets out and is heard among the lords.”
Read 4 tweets
Dr Sam Soete | Health Alchemist Profile picture
May 25
Unveiling the Paradox: Do Statins Fuel the Fire of Heart Disease?

This is a deep dive 🧵into the mechanistic relationship between statins and coronary heart disease.

#statins #CVD #heartdisease #cholesterol #mitochondria Image
The ‘bad & good cholesterol hypothesis’ has lost its foundation.

Although lowering the LDL-C/HDL-C ratio is possible with drugs such as statins, this is not effective in preventing cardiovascular disease (CVD).
Proxy measurements such as LDL-C are a breeding ground for scientific arrogance.

Does the measurement really mean what you think it means?

Have you looked into the assumptions that connect the proxy and the real thing?

Let's dig in.
Read 31 tweets
Dr Sam Soete | Health Alchemist Profile picture
May 14
Statins, given like Halloween candy to those with >10% risk of CVD, can cause insulin resistance & diabetes.

A prime example of "double think".

This 🧵 explores how statins impede insulin sensitivity & damage our pancreas.

#statins #diabetes #T2DM #CVD #cholesterol Image
Let's start off by reminding ourselves that diabetes and the broader category of metabolic syndrome is one of the leading risk factors for CVD.

Any drug that claims to be protective of CVD, should not be impeding insulin sensitivity.
Statins are associated with increased incidence of T2DM, 10-28% in some studies.

One way this happens is by a reduction in insulin secretion - a hormone that facilitates glucose uptake from the bloodstream into cells. Image
Read 27 tweets
Dr Sam Soete | Health Alchemist Profile picture
May 12
Statins are nuking your mitochondria.

This 🧵explores how statins impact our metabolic pathways and how this relates to the side-effects people experience.

#Statins #Mitochondria Image
Statins act by reversibly and competitively inhibiting HMG-CoA reductase, a key enzyme in the mevalonate pathway of which cholesterol is a final product.
Cholesterol acts as an intermediate for steroid hormones, bile acids and vitamin D, CoQ10 and is crucial to the integrity of all cell membranes.

This partly explains the plethora of statin-associated symptoms (SAS) that manifest in up to 30% of patients.
Read 25 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

Send Email!

:(