, 3 tweets, 4 min read Read on Twitter
Microbes/viruses interact to drive disease 👉 Here, a #bacteriophage (Pf) that infects bacterial pathogen p. aeruginosa (Pa)☝️promoted Pa virulence (in wounds) by triggering maladaptive anti-viral responses in human cells + suppressing bacterial clearance: science.sciencemag.org/content/363/64…
In addition 👉 1. The data suggest that a natural (unmodified) #bacteriophage may be able to produce mRNA within human cells☝️2. Consistent with a pathogenic role for Pf #phage, a vaccine against Pf phage protected against P. aeruginosa wound infections in mice
Simple summary 👉 This marks the first time a #bacteria-infecting #virus, otherwise known as a #bacteriophage...has been observed inducing the immune system to mount an antiviral response and, in doing so, causing it to ignore the bacterial infection: google.com/amp/s/medicalx…
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