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When I say #phage, do you think bacterial parasite? Superbug slayer (👀 @chngin_the_wrld)? #PhageTherapy?
Just out in @sciencemagazine, @bollyky and I find phage PROMOTE bacterial infection by directly triggering a maladaptive anti-viral immune response.
science.sciencemag.org/content/363/64…
Just out in @sciencemagazine, @bollyky and I find phage PROMOTE bacterial infection by directly triggering a maladaptive anti-viral immune response.
science.sciencemag.org/content/363/64…
ABSTRACT: Pseudomonas aeruginosa (Pa) is a multidrug-resistant Gram-negative bacterium commonly found in health care settings. Pa infections frequently result in considerable morbidity and mortality.
We find that a type of temperate filamentous bacteriophage that infects and integrates into Pa is associated with chronic human wound infections. Likewise, wounds in mice colonized with phage-infected Pa were more severe and longer-lasting than those colonized by Pa alone.
Immune cell uptake of phage-infected Pa resulted in phage RNA production and inappropriate antiviral immune responses, impeding bacterial clearance. Both phage vaccination and transfer of antiphage antibodies were protective against Pa infection.
