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Kevin Mitchell
@WiringTheBrain
, 4 tweets, 1 min read Read on Twitter
Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID) thelancet.com/journals/lanps…
Copy number variants (recurrent deletions or duplications of specific chromosomal segments) associated with risk of neurodevelopmental disorders affect multiple systems + don't have strongly distinct clinical profiles
These means focusing too much on the specific genes in each CNV may be a mistake - the symptoms are not likely linked to their biochemical activities in any direct or specific way
Instead, neurodevelopmental disorders, like autism, ADHD, anxiety disorder, may reflect general ways the brain reacts as a dynamic, self-organising system to very diverse genetic insults
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Kevin Mitchell
@WiringTheBrain
The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia rdcu.be/bBhtM - new paper from my grad student Alexandros Rammos and our collaborators, including co-supervisor Kristin Nicodemus
Given the omnigenic model (which suggests ALL genes expressed in the brain should harbor some genetic variants contributing to risk of schizophrenia) we ask whether any particular gene sets explain more of the variance than others
We do indeed find that some sets - derived from interactions with "anchor" genes like TCF4, FMR1... - capture more of the variance than expected (and develop a method to quantify that beyond just demonstrating enrichment)
Read 5 tweets
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Kevin Mitchell
@WiringTheBrain
Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies science.sciencemag.org/content/364/64… - cool paper showing how various design principles allow genetic circuits to process information
A beautiful illustration of the point I made in this recent blogpost: Were the principles of life invented or discovered? wiringthebrain.com/2019/05/were-p…
There is nothing essentially artificial about the system used in this paper. This is, IMO, the right way to think about what natural genetic circuits *do* - they are information processors. wiringthebrain.com/2017/09/what-a…
Read 3 tweets
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Kevin Mitchell
@WiringTheBrain
Sensory experience remodels genome architecture in neural circuit to drive motor learning disq.us/t/3ehtso5 - a nice, detailed elucidation of how neuronal activity changes during learning
But cue people misundertsanding this and taking it as evidence that memories are somehow stored in epigenetic patterns of gene expression in 3, 2, 1...
What it shows (in my view) is a kind of metaplasticity of neuronal state - when neurons are intensely activated they up or downregulate many genes to shift into a state primed for synaptic plasticity
Read 4 tweets

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Michael V Holmes
@mvholmes
What if I said that we had a multitude of observational studies, each showing a potential protective effect of alcohol at moderate doses on risk of heart disease and stroke. And that despite our best efforts, elucidating causality was nigh-impossible owing to (i) feasibility,
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Caroline Orr
@RVAwonk
Suicide clusters are a well documented phenomenon, particularly among young people, and media coverage plays a major role. All reporters covering this should do so cautiously, particularly when it comes to providing details about the suicide method.

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Kevin Bass, MS
@kevinnbass
Much of the low-carbohydrate diet movement is fraud. A thread. 1/n
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Yazidi
@Ezidi2
Many Yazidi ppl who survived genocide suffer from both physical & psychological trauma although some don’t apparent to b traumatized. Researchers have done a lot of studies to cover these effects on them.
This series of tweets will b about researches on Yazidi genocide survivors.
The Yezidi community continues to be targeted by ISIS. 300k vegetate in camps. 1000s of others hv bn killed are missing, or remain in captivity where they are subjected to unspeakable sexual & physical abuse.

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Adam Chekroud
@itschekkers
our new @TheLancetPsych paper was the biggest ever study of exercise and mental health. it caused quite a stir! here's my guided tour of the paper, highlighting some of our excitements and apprehensions along the way [thread] 1/n thelancet.com/journals/lanps…
the punchline was clear: amongst over 1.2M people in the USA between 2011-2015, people who exercised had about 40% better mental health than people who didn't exercise, even after we controlled for a whole bunch of things including BMI, physical health, and sociodemographics
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Adam Butterworth
@aidanbutty
Great to see the latest big paper from @Cambridge_CEU @DPHPC out in @TheLancet investigating the associations of alcohol consumption with cardiovascular disease, mortality and life expectancy: thelancet.com/journals/lance… 1/N
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