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Okay so what the hell is going on with T1AM (3-iodothyronamine) frontiersin.org/articles/10.33…
It’s an endogenous thyroid hormone metabolite discovered in 2004. As of 2014, we don’t even know its synthesis pathway. But it’s a NANOMOLAR LEVEL agonist of TAAR1, which is the primary amphetamine receptor target
And everything else it hits is Extremely Interesting. It’s practically a cocktail of every most-interesting metabolic and monoamine target 
... and did you know it upregulates dopamine synthesis through phosphorylation of tyrosine hydroxylase.... UNLIKE other TAAR1 ligands? ncbi.nlm.nih.gov/pmc/articles/P…
It’s been known for decades that thyroid hormone had a neurological effect and it’s been known for a fair while it involves TAAR1, but this is tying it together in very interesting ways
Did you know T1AM, this mysterious trace thyroid metabolite, has a specific plasma protein carrier that scoops it up as if it was as important as a hormone?
It suppressed appetite (in mice) at 1.3ug/kg while simultaneously raising plasma glucose, the precise opposite of other thyroamines
it reverted drug-induced amnesia and spurred learning.... but also appears to REQUIRE histamine and MAO-B (!) for its effect
this may be the first time (that I know of?) that MAO-B has been shown to be critical/indispensable in mammals
this may be the first time (that I know of?) that MAO-B has been shown to be critical/indispensable in mammals
anyways the thyroid / monoamine neurotransmitter linkage gets more and more curious the more it gets studied. maybe there’s something big here. frontiersin.org/articles/10.33…
Also apparently there’s only one major lab working on this (to my knowledge) and they’re mostly busy with other things so if you’re looking for a fun neuropsych project..... 😏
