Because they're attacked by histones and explode into these (never seen before) balloons (red arrows) that don't aggregate but support thrombin generation!
ncbi.nlm.nih.gov/pubmed/31405966
![](https://pbs.twimg.com/media/EB7GuVbXoAEQsdY.jpg)
![](https://pbs.twimg.com/media/EB7HsPvWkAA2G4n.jpg)
![](https://pbs.twimg.com/media/EB7LTUyWsAA5TK-.jpg)
![](https://pbs.twimg.com/media/EB7MRA7XUAAj87Q.jpg)
It took discussions with international platelet experts to finally understand that these were balloon platelets - never before seen circulating in any other human disease!
![](https://pbs.twimg.com/media/EB7M-YqWsAI6Ixt.jpg)
![](https://pbs.twimg.com/media/EB7OMSuWkAUAHV1.jpg)
![](https://pbs.twimg.com/media/EB7PNRTXYAE6WNq.jpg)
These surfaces support clot formation. Microparticles form in the process, stick to white cells & modulate the immune system.
#whoa!