🔵Janet Englund, Fred Hutch, US up next on #flu and other respiratory viruses (RespVs)
🔵slow cell/antigen based testing to PCR-based testing has vastly improved speed - notsomuch in surveillance setting
🔵 #Flu viruses not the only game in town

🔵What is "important" among RespVs
🔵34% of US kids in childcare (24% in AUS)
🔵Seattle #flu study (2018-2019)
🔵identify importation, within-host evolution, compare clinical characteristics & improve understanding in certain populations
🔵So, in childcare...
🔵things are easier now compared to decades past (e.g. Paul Glezen, only detect 31% of infections)
🔵then, newer molecular methods found 4.2 symptomatic virus episodes/child
🔵now, 103 enrolled , half the embers of each room
🔵#flu was not eh highest virus found, but responsible for a lot of missing childcare and parental work-often stayed home
🔵mean of 3.9 sample/flu season
🔵#rhinovirus the most commonly found (not commonly febrile - so still went to childcare!)

🔵the big3 were there - Respiratory syncytial virus (#RSV), human metapneumovirus (#MPV) and #Flu
🔵even the non-walking little types spread viruses well
🔵#flu % #RSV the biggest causes of childcare days & work lost
🔵 ~95% (!) were vaccinated (attenuated, quad)
🔵 A/H3N2 (dominated) component wasn't greatly effective during this study period's #flu season (2018-19)
🔵 RSV next. RSV usually precedes #flu, not this time
🔵this study highlighted that over decades, many of the same RespV patterns remain in place
🔵in a 2006-8 study, PCR-supported epidemiology identified very fast spread, lots of coinfections - in all the kids, all the time (NOT just #rhinovirus, [RV])
🔵2 or 3 viruses on day 1, a week late, 1 virus retained, and two NEW viruses! - sick all the time
🔵human bocavirus (HBoV) a big deal as well; not a virus without a disease. a primary pathogen.
🔵SO MANY different genotypes of RV - couldn't track origin
🔵options for prevention? Really don't know
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