First, a poll:
what is it about liver disease that makes vibrio vulnificus so bad for people with liver disease?
1⃣Vulnificus cases track with oyster production
2⃣Oysters from warm water are the riskiest
3⃣Cool job alert🚨: @CDCgov Epidemic intelligence service officers went 🚪-to-🚪investigating vulnificus cases. This is how the oyster connection was made.
Vulnificus is uniquely dangerous to people with iron-saturated transferrin
1⃣Normal plasma actually kills vulnificus
2⃣High hepcidin protects against vulnificus infection
And who has low hepcidin? hemochromatosis, alcohol use disorder, many w/#cirrhosis
What is the connection between liver disease and the pathogenesis of vibrio vulnificus infection?
Vibrio Vulnificus is a deadly infection:
🦠 Carried by 🦪🦪
🦠 Impacts people with liver disease
🦠 'cause they may have high Tsats
🦠 'cause the 🦠 gets iron from transferrin
So tell your patients with high Tsats: No 🦪!
This concludes a #tweetorial on how (and for whom) vibrio vulnificus impacts health. I learned a lot about the intersection of iron metabolism, evolution, and infections. And I hope you did too.