🍪
🍪🍪🍪🍪
🍪🍪Giant Cell🍪🍪
🍪🍪🍪Rich Tumors🍪🍪🍪
🍪🍪 of Bone 🍪🍪
🍪🍪🍪🍪
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#BSTPath @ariella8 @VijayPatho @Path_Matt @AbhijitSurgPath
![](https://pbs.twimg.com/media/EOaiUivW4AAltUk.jpg)
☠️Features that do NOT warrant a diagnosis of malignancy in GCT:
✖️Numerous (but typical) mitoses
✖️Necrosis (usually infarct-type)
✖️Intravascular tumor!
✖️“Benign” lung mets (that’s right!)
#BSTPath
@AlanPath @kriyer68 @angelpanizo1
![](https://pbs.twimg.com/media/EOaij4QWoAEAlcc.jpg)
![](https://pbs.twimg.com/media/EOaij6AWoAA51Il.jpg)
![](https://pbs.twimg.com/media/EOaij50XsAI9t0s.jpg)
![](https://pbs.twimg.com/media/EOaij8tXkAUvvAc.jpg)
But tumors do not always read 📚🤦🏻♀️
Here is a GCT in the hand🖐🏼.
Patient lost follow up & came back with enlarged tumor.
Bones of ✋🏼and 🦶🏼are uncommon locations for GCT of bone
(not to be confused with tenosynovial GCT which preferentially affects these sites!) #bstpath
![](https://pbs.twimg.com/media/EOaimdRX0A0mhmw.jpg)
![](https://pbs.twimg.com/media/EOaimd8X0AAEHWl.jpg)
![](https://pbs.twimg.com/media/EOaimfVW4AALIhf.jpg)
![](https://pbs.twimg.com/media/EOaimfZWoAIPy3N.jpg)
Targeted therapy with Denosumab💉 is now used.
Post-treatment changes may be confusing to the pathologist if history is lacking.
Here is an excellent example of post-Denosumab GCT by @kells108 :
![](https://pbs.twimg.com/media/EOain-wX0AI4oy-.jpg)
Case 🎢:
Gross specimen of an osteolytic lesion in distal tibia in a 10-year-old girl👇🏻
Stay tuned for Part3️⃣❗️
#BSTPath #RolaCoaster
@pembeoltulu
![](https://pbs.twimg.com/media/EOaip9KW4AId1L8.jpg)