Part2️⃣
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🍪🍪Giant Cell🍪🍪
🍪🍪🍪Rich Tumors🍪🍪🍪
🍪🍪 of Bone 🍪🍪
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#BSTPath @ariella8 @VijayPatho @Path_Matt @AbhijitSurgPath
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🍪🍪🍪🍪
🍪🍪Giant Cell🍪🍪
🍪🍪🍪Rich Tumors🍪🍪🍪
🍪🍪 of Bone 🍪🍪
🍪🍪🍪🍪
🍪
#BSTPath @ariella8 @VijayPatho @Path_Matt @AbhijitSurgPath
2/7
GCT of 🦴 continues....
☠️Secondary changes:
ABC, storiform fibrous histiocytoma-like, foam cells, focal osteoid
☠️H3F3A gene mutation (encoding histone 3.3): p.G34W
☠️IHC: G34W antibody staining the mononuclear cells
See:
GCT of 🦴 continues....
☠️Secondary changes:
ABC, storiform fibrous histiocytoma-like, foam cells, focal osteoid
☠️H3F3A gene mutation (encoding histone 3.3): p.G34W
☠️IHC: G34W antibody staining the mononuclear cells
See:
3/7
☠️Features that do NOT warrant a diagnosis of malignancy in GCT:
✖️Numerous (but typical) mitoses
✖️Necrosis (usually infarct-type)
✖️Intravascular tumor!
✖️“Benign” lung mets (that’s right!)
#BSTPath
@AlanPath @kriyer68 @angelpanizo1
☠️Features that do NOT warrant a diagnosis of malignancy in GCT:
✖️Numerous (but typical) mitoses
✖️Necrosis (usually infarct-type)
✖️Intravascular tumor!
✖️“Benign” lung mets (that’s right!)
#BSTPath
@AlanPath @kriyer68 @angelpanizo1
4/7
But tumors do not always read 📚🤦🏻♀️
Here is a GCT in the hand🖐🏼.
Patient lost follow up & came back with enlarged tumor.
Bones of ✋🏼and 🦶🏼are uncommon locations for GCT of bone
(not to be confused with tenosynovial GCT which preferentially affects these sites!) #bstpath
But tumors do not always read 📚🤦🏻♀️
Here is a GCT in the hand🖐🏼.
Patient lost follow up & came back with enlarged tumor.
Bones of ✋🏼and 🦶🏼are uncommon locations for GCT of bone
(not to be confused with tenosynovial GCT which preferentially affects these sites!) #bstpath
5/7
Targeted therapy with Denosumab💉 is now used.
Post-treatment changes may be confusing to the pathologist if history is lacking.
Here is an excellent example of post-Denosumab GCT by @kells108 :
Targeted therapy with Denosumab💉 is now used.
Post-treatment changes may be confusing to the pathologist if history is lacking.
Here is an excellent example of post-Denosumab GCT by @kells108 :
6/7
Back to this from Part1️⃣
Bx 1
41 y/o F, tibia, mid diaphysis, multicystic, 7.3cm, cortical breakthrough, fluid levels, parathyroid mass seen on U/S
Bx 2
22 y/o F, osteolytic lesion, femoral condyle, subarticular, 5 cm, cortical destruction
Much better! and the answer is👇🏻
Back to this from Part1️⃣
Bx 1
41 y/o F, tibia, mid diaphysis, multicystic, 7.3cm, cortical breakthrough, fluid levels, parathyroid mass seen on U/S
Bx 2
22 y/o F, osteolytic lesion, femoral condyle, subarticular, 5 cm, cortical destruction
Much better! and the answer is👇🏻
7/7
Case 🎢:
Gross specimen of an osteolytic lesion in distal tibia in a 10-year-old girl👇🏻
Stay tuned for Part3️⃣❗️
#BSTPath #RolaCoaster
@pembeoltulu
Case 🎢:
Gross specimen of an osteolytic lesion in distal tibia in a 10-year-old girl👇🏻
Stay tuned for Part3️⃣❗️
#BSTPath #RolaCoaster
@pembeoltulu
@threadreaderapp unroll
