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Informamos el cambio en el intervalo QT en 84 pacientes adultos con infección por SARS-CoV-2 tratados con combinación de hidroxicloroquina / azitromicina. El QTc se prolongó al máximo desde el inicio entre los días 3 y 4 | Preprint.
medrxiv.org/content/10.110…
En el 30% de los pacientes, el QTc aumentó en más de 40 ms. En el 11% de los pacientes, el QTc aumentó a> 500 ms, lo que representa un grupo de alto riesgo de arritmia.
El desarrollo de insuficiencia renal aguda pero no QTc basal fue un fuerte predictor de prolongación extrema de QTc.
Y tampoco hay evidencia de un rápido aclaramiento viral o beneficio clínico con la combinación de hidroxicloroquina y azitromicina. Aquí el paper.
sciencedirect.com/science/articl…
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