I'd like to point out that while the resolution of a #chronicillness was striking, what is more striking is the rapid descent into Wernicke's in a hospitalized 90 yo woman - a descent so striking that she went into respiratory distress necessitating a #ventilator. 1/
Upon giving #IVthiamine per a #wernickesprotocol at 200mg 3X p/d she woke up, after just 2 days of thiamine treatment, and the ventilator was removed. What could this tell us about the use of thiamine in #COVID19? Perhaps the cluster symptoms we see are really just a variation 2/
thiamine deficiency - one that is being missed by practitioners everywhere because we're not looking at the #mitochondria for answers. 3/
When we consider that most of the severe cases involve those with pre-existing #metabolic disruptions - e.g. mitochondrial issues, it is not so difficult to get from #COVID, #hypoxia, #hypoxemia to #brain and #mitochondrial distress. 4/
And when we do that - we always come back to thiamine. Other nutrients are also important - but high dose thiamine is key. I'll post this graphic once again for reference. 5/
Top of all processing pathways and throughout the #citricacidcyle what nutrient do you see most frequently? Thiamine.
Consider high dose thiamine, plus an IV nutrient bag (banana bag) for Covid -- please.
Seriously, what have you to lose? 6/
And one more thing - go back and review the symptoms for the different types of beriberi and then look at the symptoms of wernicke's - then look at your cases. How many of them fit?
Or look at the wildly different presentations of mitochondrial dysfunction. 7/
I bet you see more commonalities than you expect and when you do, it lands you right back at thiamine.
End of sermon.
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Key: "The observed pulmonary vascular dilation might be due to relative failure of normal, physiological hypoxic pulmonary vasoconstriction in the setting of overactivation of a regional vasodilatation cascade as part of a dysfunctional and diffuse inflammatory process." 2/
This leads me to hypothesize this is the site of viral injury, where #COVID binds #ACE2R's - where mito demands are the greatest - where #HIF proteins and assoc. cascades they initiate are in play - including #vasodialiation#angiogenesis and excessive #inflammation 3/
I want to talk about 2 papers that highlight the role of mitochondria in what are likely the progression of symptoms assoc with #COVID19. Note these papers are not about #covid but highlight important pathways. 1/
Key findings: apoptosis and necrosis are part of the same pathway, initiated by same mito sequences but are distinguished by time and severity, where the delimiting factor is available intracellular #ATP. 3/