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Mimicking Simple Life Without Biochemistry

Follow this thread for insights from today's SFI Seminar by Juan Pérez-Mercader (SFI + @Harvard), which you can watch live on our FB page. Recording will be saved for later viewing at this link, as well as YT:

facebook.com/santafeinstitu…
More info about today's seminar by SFI External Professor Juan Pérez-Mercader (@Harvard) on Mimicking Simple Life Without Biochemistry:

santafe.edu/events/mimicki…

#astrobiology #biochemistry #complexity
What properties characterize life? The search for a fundamental theory of #biology continues to face some serious challenges:
• n = 1
• no unified math
• can't modify carbon experimentally
• biology is still process-description
BUT: ✨ info-metabolism-replication-evolution ✨
What is the simplest possible mathematical representation of the basic qualities of living #systems?

A recipe for bare-bones physico-chemical modeling of life in inorganic substrates, according to Juan Pérez-Mercader's SFI seminar today:

santafe.edu/events/mimicki…
#autocatalysis
Simulated cell division with a "simple" stochastic reaction/diffusion model, from the research of SFI External Professor Juan Pérez-Mercader (@Harvard) et al.:
santafe.edu/events/mimicki…

#ALife @ALifeConf #oscillation #biochemistry
"They said, 'This disobeys the Second Law of Thermodynamics!' But the Second Law only applies to closed systems, and this is clearly an open system."

- Juan Pérez-Mercader on academic chauvinism that blocked work on the B-Z reaction, a crucial discovery in oscillatory chemistry:
Simulating the basic processes of life ex-novo with using inorganic chemistry:

Polymerization induced self-assembly is "not that complicated. You need some good chemists."

Juan Pérez-Mercader (SFI/@harvard) in today's SFI seminar, streaming now on FB:
facebook.com/santafeinstitu…
How to build a primitive #Turing machine from self-assembling amphiphilic polymers — on the road to a minimal viable #biology: replicating, competing, adapting inorganic chemical computers:

Today's seminar from Juan Pérez-Mercader (SFI/@Harvard):

santafe.edu/events/mimicki…
If this has piqued your interest in #autocatalysis, #abiogenesis, #biochemistry, #synthbio, and the big questions of biology, keep learning with us in our @ComplexExplorer Origins of Life course! Currently in session with open enrollment:

origins.complexityexplorer.org
The video of yesterday's SFI seminar,

"Mimicking Simple Life Without #Biochemistry"
by Juan Pérez-Mercader

"...insights into #synthbio, as well as prebiotic membrane & vesicle formation en route to proto-life and the 1st #livingsystems on early Earth."

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Related hashtags

#astrobiology #Biochemistry #complexity #biology #systems #autocatalysis #ALife #oscillation #Turing #abiogenesis #synthbio #livingsystems

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Santa Fe Institute
@sfiscience
A major step in origins of life research:

By analyzing the metabolic networks of primitive microbes, a team led by @jrcxavier incl. fmr SFI Prof Stuart Kauffman & fmr Grad Fellow @WanderingWim has identified fossils of autocatalytic sets older than both RNA and protein polymers:
Almost 50 years ago Stuart Kauffman suggested that theoretical constructs called autocatalytic sets might have been intermediates in the origin of biological complexity.

Their existence was the subject of decades of fierce debate...

More at @physorg_com:
phys.org/news/2020-03-m…
Now seems like a good time to suggest our free online #OriginsofLife course at @ComplexExplorer, currently in session with ongoing open enrollment:

🦠 origins.complexityexplorer.org
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Santa Fe Institute
@sfiscience
Today at SFI:

External Professor @DaniSBassett (@Penn) on addressing #inequity in the scientific community caused by #bias in #citation practices—focusing on the evidence of a growing #gender imbalance in the reference lists of #neuroscience research.

santafe.edu/events/citing-…
The proportion of #neuroscience papers with woman first or last authors grew from 1995 to 2018, but the undercitation of female authors actually *increased* in that time.

SFI's @DaniSBassett (@Penn) on #gender #inequity in the scientific community:
Undercitation of #neuroscience research with first or last woman authors appears to be driven predominantly by the reference lists of papers written by male-male teams.

This is not to say, however, that all men undercite women, or that women do not also undercite women:
Read 7 tweets
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Santa Fe Institute
@sfiscience
Follow this thread for coverage of our SFI Flash Workshop re: #COVID19, "After the First Wave," organized by @mikha_ehl, Cris Moore, & @svscarpino — with presentations by @meyerslab, @Caroline_OF_B, @rajivatbarnard, @glenweyl, & @sdelvall.

More info:
santafe.edu/events/after-f…
Some background from Lauren Ancel Meyers @meyerslab about the #epidemiology modeling community's efforts to produce #pandemic projections for the @CDC — first about #influenza and then, suddenly and with the models incomplete, pivoting to #COVID19:
Aggregate data from travel in and out of #Wuhan in early 2020. To infer the pace of the #epidemic, @meyerslab and colleagues used info on timing & location from first cases in other areas, travel volume to/from Wuhan, and gave an early doubling rate for #COVID19:
Read 13 tweets

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