Thread by @Bergthalerlab

Our collaborative study unravels #SARSCoV2 #SuperSpreader events in #Austria and the inter- and intra-host mutational dynamics.

Preprint at @biorxivpreprint available now: biorxiv.org/content/10.110… !

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Through #Phylogenetic #SARSCoV2 analyses and data integration with @GISAID @nextstrain , we unveiled the links between #Austrian clusters to the global #pandemic.

Explore our data and data-driven narratives at #NextstrainAustria cemm.at/research/sars-… !

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With #Epidemiological and #Phylogenetic data we investigated the geographic origins and distributions of SARS-CoV-2 in Austria. Different viruses circulated in the ski-resort region of #Ischgl with the most dominant #Tyrol-1 linked to @nextstrain clade 20C.

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With high-coverage #sequencing of the #SARSCoV2 genome we identified low-freq #mutations. Using confirmed #transmission chains and a biomathematical approach, we determined an average genetic #bottleneck size of 514 infectious viral particles across infector-infectee pairs.

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Longitudinal samples from individual #COVID19 patients depict viral intra-host time diversity with certain #mutations fluctuating in frequency over time.

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Our work demonstrates the power of integrating deep viral #sequencing and #epidemiological data to better understand how #SARSCoV2 spreads through populations. It puts forward a combined strategy to support future #pandemic control.

Find more info: cemm.at/sars-cov-2 6/7

We thank our collaborators from @MedUni_Wien, @agesnews, @MedUniInnsbruck, @Harvard, @DanaFarber, @univienna, @VetmeduniVienna, @IRBBarcelona, Kaiser Franz Josef Hospital, @icreacommunity and @broadinstitute for their great efforts. Thank you to @oeaw and @WWTF for funding.

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