Discover and read the best of Twitter Threads about #sequencing

Most recents (5)

📢🎉The work of #Bat1K is featured on the cover in the latest issue of @nature: “Six reference-quality #genomes reveal evolution of #bat adaptations” 🦇🧬 #bats Our thread 👇 on the paper:nature.com/articles/s4158… 📸: Olivier Farcy(1/n) Image
📢Have you ever wondered how 🦇 manage to do what they do? #bats have extraordinary adaptations, including powered #flight, laryngeal #echolocation, #vocal #learning and an exceptional #longevity with unique #immunity and resistance to #cancer! 📸: @DanielWhitby5 (2/n) Image
A #Bat1K team led by @Sonja_Vernes @EmmaTeeling1 @hillermich @TheGeneMyers has just published the raw genetic material that codes for these unique 🦇 adaptations and #superpowers in @nature! #bats #genomics #cool! (3/n) Image
Read 32 tweets
Our collaborative study unravels #SARSCoV2 #SuperSpreader events in #Austria and the inter- and intra-host mutational dynamics.

Preprint at @biorxivpreprint available now: biorxiv.org/content/10.110… !

1/7 Graphic design @alex_lercher
Through #Phylogenetic #SARSCoV2 analyses and data integration with @GISAID @nextstrain , we unveiled the links between #Austrian clusters to the global #pandemic.

Explore our data and data-driven narratives at #NextstrainAustria cemm.at/research/sars-… !

2/7
With #Epidemiological and #Phylogenetic data we investigated the geographic origins and distributions of SARS-CoV-2 in Austria. Different viruses circulated in the ski-resort region of #Ischgl with the most dominant #Tyrol-1 linked to @nextstrain clade 20C.

3/7
Read 7 tweets
Drawing Innovation: @illumina Super-Resolution Optics

Recently, $ILMN unveiled the NextSeq 2000, a mid-throughput sequencer w/ a ~2X reduction in operating costs ($/GB).

We think the upgrades inside the NextSeq 2000 may soon enable a $100 clinical-depth human #genome.

But how?
The cost savings come from (1) a new upfront #chemistry and (2) super-resolution optics. We think @illumina will use real-world customer data on the NextSeq 2000 to optimize 1 and 2, then possibly upgrade the #NovaSeq line.

illumina.com/systems/sequen…
I'm going to briefly (!) illustrate how #sequencing (*by synthesis*) works, walk through a farming analogy, then dive into some technical details. (Sources at the end)

Below is a general overview of a whole genome sequencing workflow (sample in, data out).
Read 19 tweets
1/13 While #COVID19 warrants our attention and swift, concerted action, we cannot forget about the existing high global burden diseases like #tuberculosis.
2/13 In ”Exact mapping of Illumina blind spots in the Mycobacterium tuberculosis genome reveals platform-wide and workflow-specific biases” preview.tinyurl.com/vyhckyc, @crobinhold1 @Valafarlab & I provide a roadmap for navigating #Illumina coverage bias when #sequencing Mtb #genomes
3/13 We use a #phylogenomic filtering step to remove evolutionary signals isolating systematically low coverage and provide lists of #Illumina #blindspots for seven #sequencing workflows (lib prep + instrument) at single-base resolution
Read 14 tweets

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