Thread by @psychopharmbris

"Further validation of the affective bias test for predicting antidepressant and pro-depressant risk: effects of pharmacological and social manipulations in male and female rats" @Dr_Hinch @doctmcgee link.springer.com/article/10.100…

Summary: #pharmacology #affectivebias #depression #animalmodels #affectivestate #malesandfemales #ABT
The need for a reliable and #translational tool measuring emotional behaviours in animals that possessing robust validity is unquestionably important but 1/

but very challenging to achieve. Commonly used assays are generally lacking in at least one aspect of #validity and do not fully translate into #clinical work. In this paper, the affective bias test (ABT) has demonstrated to reliably detect both positive 2/

and negative biases following acute pharmacological and non-pharmacological manipulations of affective state. The ABT data presented here has shown good #face, #construct, #predictive and #translation #validation of the task, and also highly replicable 3/

data of the affective bias test. The results suggest that affective biases in #learning and #memory in this assay can be equally measured in #rats of different #strains or #sex, indicating a #homological validity. The data illustrated by #meta-analysis 4/

supported those findings showing consistent, either medium or large effect sizes in both sexes and in different manipulations. 5/5
#neuroscience #sexdifferences #emotion
#academicchatter #academictwitter #phdchat #phdlife