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Kulvinder Kaur MD Profile picture
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11 Sep, 3 tweets, 3 min read
17 CORRECTIONS issued to flawed @NEJM Brazil RCT claiming early hosp #HCQ #AZM ineffective—Cavalcanti et al had failed to disclose RCT didn’t exclude pts on #HCQ #AZM in community prior to hosp adm. Renders flawed RCT inconclusive—why isn’t it retracted?
▶️nejm.org/doi/full/10.10…
2/ Important to note that the NEJM study authors concede that community use of #HCQ #AZM was widespread in Brazil, but a specific study exclusion criteria to previous HCQ AZM use was only added 5 days before the last patient was recruited for this Cavalcanti et al RCT.
3/ RCT now based on extremely controversial throw-away line in discussion: "outpatient use of these drugs (before adm) was infrequent.” No reference provided for this pivotal assumption

Additional flaws: only studied mild #COVID19 disease, in those at low risk who presented late

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More from @dockaurG

Kulvinder Kaur MD Profile picture
4 Sep
1/ US & UK media finally reporting what we've known for months from published peer-reviewed research by leading scientists🌎: pre-existing cross-protective Tcell immunity & strong Tcell responses bode well for long-term #SARSCoV2 immunity, and #HerdImmunity may already be at hand
2/ US: "We may be closer to #HerdImmunity than previously thought. Are we fearing a ‘second wave’ which our immune systems already have well in hand? People show immunological response to #SARSCoV2 in their Tcells.. without necessarily showing antibodies."
spectator.us/closer-herd-im…
3/ "#HerdImmunity may be closer than thought—UK scientists say immunity likely far higher than what govt antibody tests shows b/c it doesn't account for Tcells. Top immunologists said infection-fighting Tcells are more durable/long-lasting than antibodies"
dailymail.co.uk/news/article-8…
Read 4 tweets
Kulvinder Kaur MD Profile picture
6 Jul
Pls read #SARSCoV2 immunology🧵& subthreads for what media & “experts” are not telling you

Facts
-we have some pre-existing cross-protective immunity
-basing herd immunity only on antibodies omits strong Tcell immunity
-vaccine candidates not effective b/c don’t elicit IgA prodn
2/ Last week, researchers in Sweden and Germany also found strong T-cell responses to #SARSCoV2 which bode well for long-term immunity & found pre-existing cross-protective immunity: findings are consistent with the original US Cell study published in May.
3/ We now have three independent #SARSCoV2 studies, from teams of scientists in three different countries, all concluding the same thing:

“#COVID19 Herd Immunity Is Much Closer Than Antibody Tests Suggest”
reason.com/2020/07/01/cov…
Read 13 tweets
Kulvinder Kaur MD Profile picture
5 Jul
53+ published #HCQ studies in #COVID19—strong efficacy as prophylaxis & as treatment in early COVID19. HCQ is std of care in COVID19 tx protocols for many countries🌎 w/lowest fatality rates. Govts allowing ppl to die by blocking access to life-saving meds
c19study.com
2/#HCQ activates host anti-viral innate immunity—strong efficacy as prophylaxis & as treatment in EARLY #COVID19 esp w/in 5d of symptoms. Now we know why

CDC: >88% don't yield replication-competent #SARSCoV2 virus after 10d & viral shedding drops after 6d
cdc.gov/coronavirus/20…
3/ Recent pre-print systematic review & meta-analysis on "#SARSCoV2 viral load dynamics, duration of viral shedding & infectiousness" found:
"SARSCoV2 titres detectable in first week of illness with early peak observed at symptom onset to day 5 of illness"
medrxiv.org/content/10.110…
Read 5 tweets
Kulvinder Kaur MD Profile picture
30 Jun
Allegations of “strong evidence” for mandatory cloth masks worn by healthy ppl in public by @patrickbrownont @BonnieCrombie are absolutely false. Their decision is political. It is NOT based on known published scientific evidence on #COVID19. Here is recent Lancet systemic review
2/Even in remarks made by Peel Public Health Officer Dr Loh, he stated evidence not definitive. I must remind residents that the same Officer prev told Peel frontline HCWs w/COVID19 to return to work w/out 14d self-isolation d/t politics, not evidence. This is again more politics
3/ These politicians even admit they are acting based on public opinion. Public Health policy must NEVER be politicized—esp NEVER any mandatory actions. This is not science. Peel PH’s own study recently found 87% of #COVID19 cases are in healthcare setting
Read 4 tweets
Kulvinder Kaur MD Profile picture
4 Jun
Based on published #HCQ studies & case-controlled clinical trials, HCQ has significant efficacy in early treatment of #COVID19: PRE-exposure prophylaxis & early POST-exposure treatment. Recent NEJM RCT focused on NEITHER of these 2 key groups but rather: POST-exposure prophylaxis
2/ Here’s link to NEJM #HCQ RCT published today on POST-exposure prophylaxis given up to 4d AFTER exposure. Disturbing that science was again politically sensationalized by media before study was even published w/quotes from MD with #Gilead #BigPharma COI
nejm.org/doi/full/10.10…
3/ “The results reported by Boulware et al. are more provocative than definitive, suggesting the potential prevention benefit(s) of #Hydroxychloroquine remain to be determined,” concluded Dr. Myron Cohen MD in NEJM editorial re recent NEJM HCQ #COVID19 RCT
nejm.org/doi/full/10.10…
Read 4 tweets
Kulvinder Kaur MD Profile picture
26 May
Imp Thread: public health fallacy to claim popn #SARSCoV2 IgG serology tests capture all pts recovered from #COVID19: grossly UNDERestimates % popn that was asymptomatic & recovered. Key arms of immune response to #SARSCoV2: humoral with antibodies & cell-mediated with T-cells
2/ Current public health method to estimate population immunity to #SARSCoV2 from recovered asymptomatic #COVID19 ppl uses serology tests to detect IgG antibodies: this only captures humoral immunity. Currently no widely available testing kit for T-cell immunity to #SARSCoV2
3/ Pts mount strong T-cell immune responses to #coronaviruses. Published Cell research & studies on recovered #COVID19 pts w/immunodeficiency disorders w/inability to mount B-cell responses to #SARSCoV2 reveal B-cell antibody responses not strictly required to overcome COVID-19
Read 6 tweets

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