#Coronavirus Reinfection:
🧬1st infection: April (symptomatic)
🧬2nd infection: June (symptomatic*)
*Required hospitalization, O₂
🧬Two virus genomes differed by 11 nucleotides
▪️Case A: 4 variants not in case B
▪️Case B: 7 variants not in case A
👉thelancet.com/journals/lanin…
🧬1st infection: April (symptomatic)
🧬2nd infection: June (symptomatic*)
*Required hospitalization, O₂
🧬Two virus genomes differed by 11 nucleotides
▪️Case A: 4 variants not in case B
▪️Case B: 7 variants not in case A
👉thelancet.com/journals/lanin…
SARS-CoV-2 #Reinfection:
🧬4 reversions to ref genome proves 2nd infection not tied to 1st infection
🧬2nd infection caused by new infection, not prolonged viral shedding
🧬Patient tested positive for IgM/IgG against SARS-CoV-2 nucleoprotein when hospitalized for 2nd infection
🧬4 reversions to ref genome proves 2nd infection not tied to 1st infection
🧬2nd infection caused by new infection, not prolonged viral shedding
🧬Patient tested positive for IgM/IgG against SARS-CoV-2 nucleoprotein when hospitalized for 2nd infection
4 Reversions:
🧬Calculate the probability that 4 variants in 1st infection (Case A) [that aren’t in 2nd infection (Case B)] mutated back to ref genome
🧬It’s the only way 1st infection could have mutated to become 2nd infection
🧬= ~1 chance in 10^18
🧬Odds exceedingly remote
🧬Calculate the probability that 4 variants in 1st infection (Case A) [that aren’t in 2nd infection (Case B)] mutated back to ref genome
🧬It’s the only way 1st infection could have mutated to become 2nd infection
🧬= ~1 chance in 10^18
🧬Odds exceedingly remote
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