#B16171 variant is 6.8-fold less susceptible to neutralization by sera from infection & vaccinated (Pfizer & Moderna) subjects. Despite this, most of the sera from convalescents (79%) & all from vaccinated subjects were still able to neutralize the variant biorxiv.org/content/10.110…
#Covaxin retains efficacy against #B1617: Only minimal reductions in the neutralization observed against B1617; Neutralization reduction by a factor of 1.95 & 1.8 was observed against the B1617 variant for B1 (D614G) & B117 variant, respectively. biorxiv.org/content/10.110…
#B16171 variant is highly pathogenic in hamsters than B1 (D614G) variant! B1617 demonstrates higher pathogenicity evident with reduced body weight, higher viral load in lungs & pronounced lung lesions as compared to B1 biorxiv.org/content/10.110…
Potential impacts of #B1617 variant on Vaccine Effectiveness or therapeutics, or reinfection risks, remain uncertain. However, it is highly transmissible. Lab studies suggest a limited reduction in neutralization by antibodies; however, real-world impacts may be limited

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Vipin M. Vashishtha

Vipin M. Vashishtha Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @vipintukur

13 May
The #Indian variant (#B16172) may be the most transmissible variant yet identified!!
This variant is 60% more transmissible than the #UK variant (#B117), & 2.6 times more transmissible than the original strain (B1)! Image
The #B16172 has now become the dominant variant in almost all key states on India. Data patchy (n=4480 since Jan. 2021 of which 1690 B.1.617+) but clear patterns. Data courtesy @TWenseleers Image
According to a new modelling study shared by @TWenseleers, the Indian VOC #B16172 would have a growth rate advantage of 7% per day over B.1.617.1 or of 10% per day relative to the UK variant B.1.1.7. ImageImage
Read 5 tweets
12 May
A very interesting yet a bit complicated paper. First, let’s go through the key findings of the paper:

1) the distribution of viral loads observed in asymptomatic population was indistinguishable from what has been reported in hospitalized populations 1/
2) regardless of symptomatic status, approx. 50% of individuals who test positive for #SARSCoV2 seem to be in noninfectious phases of the infection 2/ pnas.org/content/118/21…
3) just 2% of infected individuals carry 90% of the virions circulating within communities, serving as viral “supercarriers” & likely also superspreaders 3/

pnas.org/content/118/21…
Read 9 tweets
10 May
The WHO declared a coronavirus variant first identified in India, B.1.617, as a “variant of concern,” the agency’s fourth such designation wsj.com/articles/coron…
One can understand the gravity of this announcement: The Indian variant, #B1717 is now clubbed with UK #B117, SA #B1351 & Brazil’s #P1
I think this data is saying "Take B.1.617 very seriously and surge test, contact trace, support isolation of cases & contacts, ring vaccinate - NOW" @chrischirp Look, experts from UK are sounding alert on a variant originated from here! And what was our response?
Read 6 tweets
5 May
Is there any role of large-scale vaccination in containing the ongoing surge in #India? The current estimate of herd immunity threshold is around 60%-70% based on the estimate with old variant #D614G. 1/
With the advent of new, more transmissible #variants, the estimate for a herd immunity threshold may further go up. The pace of inoculation is very sluggish, inoculated a meagre 2.0 % of our population with 2 doses! May take few years to reach anywhere near the threshold 2/
We are currently on the ascending limb of an outbreak propelled by a highly transmissible virus with a high reproduction number (Ro). Further, there is confusion over what it means to reach herd immunity 3/
Read 15 tweets
4 May
Have we reached to the peak of 2nd #Covid wave in India? May be, yes! Its already 2.5 months in to it. Most badly affected countries peaked within 1.5-3 months of onset of a new surge. Is it too early to comment? 1/
More interesting would be to see which way our curve goes: the UK/Israel or the US way! While both UK/Israel took 1.5-2 months to flatten their curves w/ strict lockdowns & aggressive vaccination, US had a long plateau (>3.5 months) 2/
However, there is heterogeneity in caseloads: While states like MH, UP, CG, PB, DL are showing ⬇️ in case load, some southern & eastern states (KA, KL, AP, TN, WB, ) still reporting cases in high numbers! What is driving Covid in these states? 3/ indiatoday.in/coronavirus-ou…
Read 9 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

:(