Here is a link to the @MMWR with the data from the #Provincetown outbreak which led @CDCgov to change their recommendation on #Masks due to the #DeltaVariant

Here is a🧵highlighting the important points
1/

cdc.gov/mmwr/volumes/7…
-There were 469 cases of #COVID19 in Barnstable, MA in July 2021
- 346 (74%) cases in fully #vaccinated
- #Sequencing in 119/133 (89%) specimens confirmed #DeltaVariant
-274 (79%) with breakthrough infection were symptomatic
-4/5 hospitalized were fully #vaccinated

2/
-Ct value similar in fully vax'd (127) vs. those not (84) (22.7 vs 21.5)
-Most cases in males (85%); median age 40
-Time from vax completion -> infection 86 d (6-178 d)
- Vax as cause for breakthrough
#PfizerBiontech (159,46%)
#Moderna (131,38%)
#Janssen (56,16%)

3/
274 (79%) w/ breakthrough infection had si/sx
- Cough
- Headache
- Sore throat
- Muscle aches
- Fever

4/
What does this mean?
- Confirms the #DeltaVariant is bad
- People who have non-specific symptoms even if #vaccinated should be concerned about #COVID19
- Delta causes similar viral load in those vax'd vs those who are not

5/
Questions from these data
- Why was there such a propensity for men (85%) to have breakthrough
- Was severity of disease different the further out from #vaccine individuals were
- What were Ab titers in those with breakthrough
- Does being vax'd protect against #LongCovid

6/

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More from @KrutikaKuppalli

30 Jul
Here is some of the @CDC data that was looked at and published by @washingtonpost to make the recommendations to re-implement #masks earlier this week

Note that the #DeltaVariant is MORE transmissible than
- MERS & SARS
- Ebola
- Seasonal Flu and the Flu of 1918
- Smallpox
1/
#DeltaVariant associated with lower Ct value in breakthrough cases, longer duration of Ct < 30, and higher risk of re-infecton
2/
Breakthrough cases of #DeltaVariant have ~ 10 fold increase in viral load compared to alpha or other lineages
3/
Read 7 tweets
14 Apr
1/
Information regarding the six patients who have developed CVST after the #JohnsonandJohnson #CovidVaccine
- All were white females
- Only one was on oral contraceptives
2/ Clinical features of the patients
3/ Location of CVST
Read 8 tweets
10 Jan
Thoughts on #CovidVaccine Rollout

I see a lot of suggestions/posts about #vaccine rollout and since I have been involved with this thought I would provide insight based on my experiences

See thread below 👇

1/
1. Expecting our hospitals/healthcare systems to absorb the #CovidVaccine rollout without support is unreasonable.

- Hospitals are running on empty and short staffed trying to manage caring for patients
- Rolling out this vaccine takes a lot of support and planning

2/
2. The lack of federal coordination is making this increasingly complex

- Each state has its own plan and within each state each hospital has its own plan
- There is no uniformity
- This leads to disparities between and within states

3/
Read 9 tweets
13 Dec 20
Since I am helping lead the #Pfizer #CovidVaccine rollout at our institution I have spent a lot of time doing town halls and engaging with people on the vaccine.

One of the most common questions I get is in regards to side effects so I thought I would post my slides
Overall localized side effects of the #CovidVaccine
Overall systemic side effects of the #CovidVaccine
Read 4 tweets
7 Nov 20
I want people to understand what we mean when we say that hospitals are at "capacity"

- That means there are no more beds for patients
- If you are in a trauma and need care there is not a bed
- Your elective surgery cardiac cath, or biopsy is will be postponed
- When you come to the Emergency Room you are going to wait much longer because doctors and nurses are busy trying to manage all the patients
- You may have to stay in a bed in a hall (if you are lucky)
- Nurses will be further stretched and have less time to tend to you
- It will take longer to get your x-ray, blood draws, and any other tests you need
- Doctors will have more patients to take care of and are unable to spend as much time thinking about your care

Normally we would be able to get backup from other areas, but not in a pandemic
Read 4 tweets
7 Nov 20
Given the #surge of #COVID19 in the US we need to focus on containing the pandemic. Here are some things we need
1. We need a #NationalPlan to combat this infection
- Right now we have 50 states doing 50 different things
2. Scale up testing
- Use of PCR, saliva, rapid, Ag
1/
3. Focus on community engagement at the local, state, and national level
- Empower communities and people to be proactive
4. Statewide #MaskMandates
5. Limitations on crowd and gathering sizes
6. Support of I&Q
- Paid sick leave, mental health, and healthcare
-Food delivery
2/
7. Scale up of contact tracing once we get case counts lower
8. Support for public health departments and schools so they can carry out recommendations
9. Support for heathcare workers who are burned out
10. Scale up PPE production
11. Financial support for small businesses
3/
Read 4 tweets

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