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Laurel Coons 🧬🧬🧬

@LaurelCoons

24 Aug 20

#Coronavirus Reinfection:

🧬1st infection: March (symptomatic)

🧬2nd infection: August (asymptomatic)

🧬Two virus genomes differed by 24 nucleotides

🧬Proves that 2nd infection was not tied to 1st infection

🧬2nd infection caused by #reinfection, not prolonged viral shedding

Neutralizing Antibody:

🧬Tested NEGATIVE for IgG against SARS-CoV-2 nucleoprotein 10 days after symptom onset of 1st infection AND 1 day after hospitalization for 2nd infection

🧬Thus unknown if patient mounted neutralizing antibody response to 1st infection, didn’t last if yes

Immune Response Following 2nd Infection:

🧬Patient tested POSITIVE for IgG against SARS-CoV-2 nucleoprotein 5 days after hospitalization for 2nd infection

🧬Most patients do develop immune response to infection, unclear how #strong that immune response is and how long it #lasts

Read 4 tweets

Laurel Coons 🧬🧬🧬

@LaurelCoons

25 Apr 19

@nature

National DNA Day:

🧬April 25

🧬Commemorates the day in 1953 when Watson, Crick, Wilkins, Franklin and colleagues published papers in the journal @nature on the structure of DNA

🧬Also commemorates the completion of the Human Genome Project in April 2003, took 13 years

#DNADay

DNA Double Helix:

🧬The two #DNA strands are reverse-complements

🧬Reading one strand in #reverse order and exchanging each base with its #complement gives the other strand

🧬A and T are complements, C and G are complements

DNA Sequence: AGTAGCAT
Reverse-Complement: ATGCTACT

In #Each DNA Strand:

🧬Pull the #DNA double helix apart, leaving the two single DNA strands

🧬The population (or occurrence) of every DNA sequence in that single-strand is #equivalent to the population of its reverse-complement DNA sequence in that same single-strand

#Genomics

Read 5 tweets

Laurel Coons 🧬🧬🧬

@LaurelCoons

12 Apr 19

Data Needs A Home:

🧬The population of every DNA word is equivalent to the population of its reverse-complement DNA word in the SINGLE-STRANDED human genome

🧬Population count of 1.4 trillion DNA words

🧬Does anyone want a copy of this data before files are deleted?

#Genomics

Can You Use This #Data?

🧬Demonstrates the inherent inversion symmetry structure for all DNA elements in the single-stranded genome

🧬Demonstrates the absence of analog symmetries between reverse pairs and complement pairs of DNA elements

#BigData
🔂

👉cell.com/iscience/fullt…

Do You Know Anyone 🏷 Who Can Use This Data?

🧬The number of times every #DNA element (1-nt to 20-nt) occurs in the single-stranded genome

🧬This inversion symmetry structure is also maintained at the level of each individual #chromosome, except chromosome M (mitochondrial DNA)

Read 6 tweets

Laurel Coons 🧬🧬🧬

@LaurelCoons

30 Jan 18

DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin:

1336 Datasets:

Defining NR Functional Enhancers (NRFEs)
#sNRFunctionalNRFE

Enhancer Activation
#IndicatorNRFE

sNR Cross-Talk
#sNRCrossTalkNRFE

doi.org/10.1210/en.201…

Functional Genomics:

📌Describes the relationship between an organism’s genotype (genetic makeup, DNA sequence) and phenotype (observable traits) on a global scale

📌A key characteristic is the genome-wide scale, rather than a more traditional “gene-by-gene” approach

#Genomics

DNA→RNA→Protein:

📌Genes:
-Blueprint for life
-Made of DNA
-Act as instructions to make proteins

📌Gene Expression:
DNA sequence is first copied to make an RNA molecule (transcription),
which is then "decoded" to build a protein (translation)

Proteins=Building Blocks Of Life

Read 8 tweets

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