This is such a fantastic Summary of semiological signs by symptomatogenic zone on mesial and lateral structures. DLPFC, dorsolateral prefrontal cortex; SMA, supplementary motor area.
Temporal and frontal lobe seizures differentiating
semiological features
The best part of the review.."Localising value of auras"; a succinct Table
Key points
► Seizure(Sz) semiology reflects altered electrical activity in the affected part of 🧠.
► Szs can manifest as motor, subjective &
behavioural phenomena, or loss of awareness,
& careful analysis of their semiology can allow
localisation of Sz onset.
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Metabolic acidosis is a chronic condition that
many people in the Western world have but
do not realize it... It occurs when there is
retention of acid in the body, which leads to
a depletion in the bicarbonate stores of the
body. Ways to test for low-grade metabolic acidosis👇
what are the Four main mechanisms that compensate for chronic latent metabolic acidosis?
#SARS-CoV-2 nucleocapsid protein (NP) was detected in the colon, appendix, ileum, haemorrhoid, liver, gall- bladder and lymph nodes from 5 pts who recovered from COVID-19, ranging from 9 to 180 days after testing -ve for SARS-CoV-2. #MedTwitter
Although resp transmission is responsible for most COVID-19 inf, there is ⬆️ evidence of COVID-19 causing GI & hepatic manifestations, as studies reported the presence positive SARS-CoV-2 RNA in anal swabs & stool samples, despite NP or sputum specimens testing -ve for the virus
Weeks after #SARS-CoV-2 inf or exposure, some children develop a severe, life-threatening illness called Multisystem Inflammatory Syndrome in Children (#MIS-C). GI symptoms are common in MIS-C pts & severe hyperinflammatory response ensues with potential for ❤️ complications.
👉🏽As proof of concept, they treated a #MIS-C patient with #larazotide, a #zonulin antagonist, & monitored impact on antigenemia and clinical response.
👉🏽in MIS-C, prolonged + of SARS-CoV-2 in t GI tract ➡️ to release of zonulin, a biomarker of intestinal permeability,
This gentle man is Sir William Osler.. He has frequently been described as the “Father of Modern Medicine” and one of the "greatest diagnosticians ever to wield a stethoscope". What did he hv to say about #India ? @sanjeevsanyal@vipintukur@naveenthacker@EricTopol@mvankerkhove
In one of his essays; “Of India, of "Vishnu-land," what can one say in a few minutes? To the Hindoos we owe a debt which we can at any rate acknowledge; and even in medicine, many of our traditions and practices may be traced to them”. @drharshvardhan@PMOIndia@BharadwajSpeaks